Comparison and evaluation of Abbott chemiluminescent microparticle immunoassay and ChIVD light-initiated chemiluminescent assay in the detection of Treponema pallidum antibody.

Journal of Clinical Laboratory Analysis
Xiaohui ChenLiyan Cui

Abstract

Laboratory tests play an important role in the diagnosis of syphilis. This study aimed to compare and assess the performance of the Abbott chemiluminescent microparticle immunoassay (CMIA) and the ChIVD light-initiated chemiluminescent assay (LICA) in the detection of Treponema pallidum (TP) antibody. A total of 10 498 serum samples were detected with two assays, and the Treponema pallidum particle agglutination assay (TPPA) and recombinant immunoblot assay (RIBA) methods were used for confirmation. The sensitivity, specificity, positive predictive value, and negative predictive value of the Abbott CMIA and ChIVD LICA were calculated. The coincidence rate between two assays was also evaluated. The causes of false positive and false negative of two assays were studied. For the Abbott CMIA and ChIVD LICA, the sensitivity was 94.44% and 98.15%, the specificity was 99.89% and 99.81%, the positive predictive value was 93.29% and 88.83%, and the negative predictive value was 99.91% and 99.97%, respectively. The coincidence rate between Abbott CMIA and ChIVD LICA was 99.26%, and κ value was .790. The disease of infertility, hypertensive disease, liver disease, and cancer were the common causes of false positive in both assays, while i...Continue Reading

References

Jan 30, 2007·Journal of Biomolecular Screening·Fritz Poulsen, Kirsten Borres Jensen
May 25, 2012·Asian Journal of Transfusion Science·Narinder Kaur NaiduImran Ahmed
Oct 29, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M JanierR Patel
Aug 28, 2015·Infectious Diseases·Ke-Di WangJian-Rong Su
Apr 21, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Xingyu ZhangTao Zhang
Mar 31, 2017·Microbial Cell·Lola V Stamm
Aug 26, 2017·Annals of Laboratory Medicine·Eun Hee NahJong Yil Chai
Jul 10, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ina U ParkGail Bolan
Dec 6, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Junpu LiHuiqiang Li

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