β-Cyclodextrin covalent organic framework-modified organic polymer monolith as a stationary phase for combined hydrophilic and hydrophobic aqueous capillary electrochromatographic separation of small molecules

Mikrochimica Acta
Mingxuan MaJiangxia Yang

Abstract

A β-Cyclodextrin covalent organic framework (β-CD COF) was successfully prepared under ambient temperature with a mild chemistry strategy from heptakis(6-amino-6-deoxy)-β-cyclodextrin and terephthalaldehyde. It was embedded into the poly[(glycidyl methacrylate)-co-(ethylene dimethacrylate)] [poly(GMA-co-EDMA)] monolith and served as the β-CD COF material-incorporated monolith. The synthetic materials were characterized by field emission scanning electron microscopy, energy-dispersive X-ray mapping analysis, transmission electron microscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy, and N2 adsorption-desorption isotherm. The β-CD COF material-incorporated monolith achieved baseline separation in capillary electrochromatographic separation of three amides, three amino acids, three nucleosides, four aromatic acids, and three positional isomers (with resolution values of three amides, 1.75 and 1.54; three amino acids, 5.24 and 1.75; three nucleosides, 2.56 and 1.77; four aromatic acids, 6.96, 2.74, and 1.64; three positional isomers, 1.61 and 1.50). In comparison with the original monolith, the β-CD COF material-incorporated monolith shows significantly enhanced resolution for mixed molecules. The effect ...Continue Reading

References

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Citations

Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jenni J JarjuLaura M Salonen
Oct 6, 2021·Macromolecular Rapid Communications·Jun-Feng FengBang-Jing Li
Jan 27, 2022·Journal of Separation Science·Katerina FikarovaFernando Maya

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