β-endorphins Plasma Level is Higher in Lean Polycystic Ovary Syndrome (PCOS) Women

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
M KiałkaJ Krzysiek

Abstract

The evaluation the β-endorphin plasma levels in lean women with polycystic ovary syndrome as well as in women without this disorder. The associations between β-endorphins and other laboratory parameters were also investigated. 31 women lean, defined as women with normal range body mass index, 15 with polycystic ovary syndrome and 16 without this disorder were included to the study. In all the patients the level of β-endorphins was measured. Also the diagnostic laboratory profile including hormone assessment was made in all patients. There were significant differences in β-endorphin levels between the 2 groups. The β-endorphin level was higher in the polycystic ovary syndrome group compared to the healthy controls (15.5±4.37 pg/ml vs. 6.9±2.47 pg/ml, p<0.0001). The β-endorphin levels positively correlated with cortisol at 8 am (R=0.632, p=0.011) and negatively correlated with sex hormone binding globuline (R=0.518, p=0.0478) in polycystic ovary syndrome group. Increase in β-endorphin level of 1 pg/ml was associated with an increase of cortisol at 8 am level of 1.134 µg/dl and decrease of sex hormone binding globuline of 0.948 nmol/l in polycystic ovary syndrome group. Our study showed that the levels of β-endorphins were signifi...Continue Reading

Citations

Nov 29, 2020·Archives of Gynecology and Obstetrics·Chan ZhangFang Wang
Apr 6, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jiby Jolly BenjaminPadmavathi Ramaswamy
Jul 24, 2021·Evolutionary Applications·Natalie L Dinsdale, Bernard J Crespi

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