β-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1α/TGF-β/MMPs in A549 cells.

Toxicology Research
Chermakani Paneerselvam, Sudhandiran Ganapasam

Abstract

Hypoxia is contributed in various pathophysiological conditions including obesity, cardiovascular diseases, and cancer. In cancer, hypoxia is a salient phenomenon and has been correlated with tumor progression, metastasis, and provoke resistance to therapies in cancer patients, which exert with stabilization of main effector, hypoxia inducible factor-1 alpha (HIF-1α). Therefore, therapeutic targeting of hypoxic responses in cancer is the potential approach to improve the better treatment efficacy. In the present study, we evaluated the effect of β-Escin (β-Es) on hypoxia-induced resistance to apoptosis and metastasis in human non-small-cell lung cancer cells. The MTT assay revealed that β-Es treatment decreased the A549 cells viability under cobalt chloride-induced hypoxia. Apoptotic proteins were analyzed by western blot that showed cancer cells treated with β-Es induced cell death in hypoxia condition as proteins compared with normoxia. Moreover, we observed that cobalt chloride induced hypoxia through the generation of intracellular reactive oxygen species and stabilized the transcriptional factor HIF-1α, which leads to cancer metastasis. This notion was supported by the migration, invasion, and adhesion assays. Furthermore,...Continue Reading

References

Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R Sirtori
Jul 17, 2004·American Journal of Respiratory Cell and Molecular Biology·Georgia ChachamiEfrosyni Paraskeva
Jul 24, 2004·The Journal of Biological Chemistry·Konstantin SalnikowKazimierz S Kasprzak
Jul 9, 2005·Cancer Letters·Jie ZhouBernhard Brüne
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Sep 27, 2007·Journal of the National Cancer Institute·Olivier TrédanIan F Tannock
Oct 11, 2008·International Journal of Cancer. Journal International Du Cancer·Wen-Jie HuangUNKNOWN De-AnTian
Nov 5, 2008·Cancer Biology & Therapy·Jie Wang, Jing Yi
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Simone Fulda
Oct 6, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Guofei ZhouJacob I Sznajder
Oct 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin Lu, Yibin Kang
Apr 1, 2011·Phytotherapy Research : PTR·Zhenzhen ZhangPeng Cao
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nicolas LecomteSamuel J Danishefsky
Mar 29, 2012·Journal of Experimental & Clinical Cancer Research : CR·Zhi-Jun DaiXi-Jing Wang
Sep 5, 2012·Journal of Translational Medicine·Lenka KubiczkovaSabina Sevcikova
Dec 1, 2012·Archives of Pathology & Laboratory Medicine·Larry NicholsFriedrich D Knollmann
Feb 11, 2014·Journal of the National Cancer Institute·Daniel R PrincipePaul J Grippo
Apr 16, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yiping LiuXiaodong Chen
May 16, 2014·Nature Reviews. Cancer·Daniele M GilkesDenis Wirtz
Jan 30, 2016·Acta biochimica Polonica·Gabriela MojžišováJán Mojžiš
May 20, 2016·Annals of Translational Medicine·Joanna DidkowskaJakub Łobaszewski
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Nov 5, 2016·Biochimica Et Biophysica Acta·Maureen Redza-Dutordoir, Diana A Averill-Bates
Mar 18, 2017·International Journal of Molecular Sciences·Thazin Nwe AungDavid L Adelson
Jun 24, 2017·Carcinogenesis·Neha MerchantArif N Ali
Jul 30, 2017·International Journal of Molecular Sciences·Dimakatso Alice SenthebaneKevin Dzobo
Feb 24, 2018·Cancer Letters·Dorothy H J CheongThai Tran
Apr 1, 2019·Molecular Cancer·Zehuan LiaoNguan Soon Tan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2021 Meta ULC. All rights reserved