α-Fluoroallenoate Synthesis via N-Heterocyclic Carbene-Catalyzed Fluorination Reaction of Alkynals

Organic Letters
Xu WangJian Wang

Abstract

The first catalytic α-fluoroallenoate synthesis is described. With a suitable combination of N-heterocyclic carbene precatalyst, base, and fluorine reagent, the reaction proceeded smoothly to yield a wide range of α-fluoroallenoates with excellent chemoselectivity. These substituted α-fluorinated allenoates have been synthesized for the first time, and they are versatile synthetic intermediates toward other useful fluorine-containing building blocks.

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Citations

Sep 21, 2016·The Journal of Organic Chemistry·Sourav JanaAlakananda Hajra
May 26, 2017·Organic & Biomolecular Chemistry·Qiao RenJian Wang
Mar 30, 2017·Organic & Biomolecular Chemistry·Debanjan Bakshi, Anand Singh

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