β-glucan restores tumor-educated dendritic cell maturation to enhance antitumor immune responses

International Journal of Cancer. Journal International Du Cancer
Yongling NingChunjian Qi

Abstract

Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendritic cells (TEDCs) involved in the tolerance induction have attracted much attention recently. In this study, we investigated the effect of β-glucan on TEDCs and found that β-glucan treatment could promote the maturation and migration of TEDCs and that the suppressive function of TEDCs was significantly decreased. Treatment with β-glucan drastically decreased the levels of regulatory T (Treg) cells but increased the infiltration of macrophages, granulocytes and DCs in tumor masses, thus elicited Th1 differentiation and cytotoxic T-lymphocyte responses and led to a delay in tumor progression. These findings reveal that β-glucan can inhibit the regulatory function of TEDCs, therefore revealing a novel function for β-glucan in immunotherapy and suggesting its potential clinical benefit. β-Glucan directly abrogated tumor-educated dendritic cells-associated immune suppression, promoted Th1 differentiation and cytotoxic T...Continue Reading

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Citations

Oct 21, 2016·Cancer Immunology, Immunotherapy : CII·Claire BartonJames F Spicer
Nov 14, 2016·International Journal of Biological Macromolecules·Li MoYong Zhan
Sep 26, 2019·Microbiology and Immunology·Chenglong MaChunjian Qi
Jul 18, 2020·Journal of Leukocyte Biology·Li-Juan DengJia-Xu Chen
Aug 9, 2018·Medical Microbiology and Immunology·Jun DingChunjian Qi
Jul 25, 2019·Applied Microbiology and Biotechnology·Ravindra Pal Singh
Dec 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xing ZhengLina Zhang
Mar 7, 2020·Journal of Ovarian Research·Shahla ChaichianZatollah Asemi
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Apr 23, 2021·Advanced Drug Delivery Reviews·Juan GuanChangyou Zhan
Sep 12, 2020·Chemical Reviews·Wen-Hao Li, Yan-Mei Li

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