α-glucosidase inhibitors from Brickellia cavanillesii

Journal of Natural Products
Sonia Escandón-RiveraRachel Mata

Abstract

An aqueous extract from the aerial parts of Brickellia cavanillesii attenuated postprandial hyperglycemia in diabetic mice during oral glucose and sucrose tolerance tests. Experimental type-II DM was achieved by treating mice with streptozotocin (100 mg/kg) and β-nicotinamide adenine dinucleotide (40 mg/kg). These pharmacological results demonstrated that B. cavanillesii is effective for controlling fasting and postprandial blood glucose levels in animal models. The same aqueous extract also showed potent inhibitory activity (IC(50) = 0.169 vs 1.12 mg/mL for acarbose) against yeast α-glucosidase. Bioassay-guided fractionation of the active extract using the α-glucosidase inhibitory assay led to the isolation of several compounds including two chromenes [6-acetyl-5-hydroxy-2,2-dimethyl-2H-chromene (1) and 6-hydroxyacetyl-5-hydroxy-2,2-dimethyl-2H-chromene (2)], two sesquiterpene lactones [caleins B (3) and C (4)], several flavonoids [acacetin (5), genkwanin (6), isorhamnetin (7), kaempferol (8), and quercetin (9)], and 3,5-di-O-caffeoylquinic acid (10). Chromene 2 is a new chemical entity. Compounds 2, 4, 7, and 9 inhibited the activity of yeast α-glucosidase with IC(50) 0.42, 0.28, 0.16, and 0.53 mM, respectively, vs 1.7 mM for...Continue Reading

References

Nov 24, 1999·Journal of Agricultural and Food Chemistry·T OkiY Osajima
Nov 16, 2004·Phytochemistry·Masashi YamadaMunekazu Iinuma
Jun 21, 2005·Journal of Ethnopharmacology·Adolfo Andrade-Cetto, Michael Heinrich
Jul 22, 2005·Journal of Medicinal Chemistry·Svea MeieringR Luise Krauth-Siegel
Jun 29, 2006·Journal of Nutritional Science and Vitaminology·Kenjiro TaderaTomoko Matsuoka
Feb 3, 2007·Journal of Computational Chemistry·Ruth HueyDavid S Goodsell
Oct 3, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yong Rok LeeLikai Xia
Nov 8, 2007·Magnetic Resonance in Chemistry : MRC·Younghee ParkYoongho Lim
May 30, 2008·Journal of Medicinal Chemistry·Elena Lo PiparoChieh Jason Chou
May 1, 2009·Nature Reviews. Drug Discovery·Nigel A CalcuttAnn Marie Schmidt
Oct 1, 2010·Journal of Natural Products·Fernando BrindisRachel Mata

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Citations

Dec 18, 2013·International Journal of Biological Macromolecules·Jiakai YanYajie Wang
Feb 13, 2013·Journal of Natural Products·Rachel MataIsabel Rivero-Cruz
Mar 12, 2013·Acta Crystallographica. Section E, Structure Reports Online·Dongsoo Koh
Jan 7, 2015·International Journal of Molecular Sciences·Hui-Yu FangJyh-Horng Sheu
May 13, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Si-Yao LiuZhi-Qi Zhang
Sep 5, 2015·Journal of Agricultural and Food Chemistry·Yan-Yan MaKun Zhang
Nov 17, 2015·Chemistry & Biodiversity·Ya-Long ZhangLing-Yi Kong
Jul 28, 2015·Food Chemistry·Xi PengDeming Gong
Dec 10, 2014·Journal of Ethnopharmacology·Krutzkaya Juárez-ReyesRachel Mata
Feb 25, 2015·Molecular Phylogenetics and Evolution·Edward E SchillingPatricia Dávila
Oct 14, 2014·Acta Crystallographica. Section E, Structure Reports Online·Dongsoo Koh
Jun 4, 2014·Journal of Ethnopharmacology·Gerardo D Anaya-EugenioRachel Mata
Jul 7, 2016·Journal of Ethnopharmacology·Gabriela Ávila-VillarrealSamuel Estrada-Soto
Jun 18, 2017·Organic Letters·Jiuzhong HuangHuanfeng Jiang
Dec 21, 2018·International Journal of Environmental Health Research·Mohamad Fawzi MahomoodallyMuhammad Zakariyyah Aumeeruddy
Sep 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sonia Marlen Escandón-RiveraAdolfo Andrade-Cetto
Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sonia Escandón-RiveraRachel Mata
Jan 21, 2021·Nature Communications·Kai YangQiuling Song
Sep 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shilpi SinghSuaib Luqman
May 15, 2020·Current Drug Metabolism·Deependra Singh ChauhanMohd Amir
May 4, 2021·Journal of Bioscience and Bioengineering·Kesinee Nanok, Sompong Sansenya
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Jiménez-EstradaAna Berenice Alvarez
Aug 28, 2021·Foods·Elizabeth BarberGary Williamson
Sep 1, 2021·Primary Care Diabetes·Yeniley Ruiz-NoaAlfredo Lara-Morales

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