γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors

Human Pathology
Kosuke TakemuraPhilip G Board

Abstract

Recently, overexpression of γ-glutamylcyclotransferase (GGCT) has been reported in various cancer tissues suggesting that it has significant potential as a diagnostic marker. The aim of this study was to examine the suitability of GGCT for the detection of high-risk lesions at an early stage of esophageal squamous cell carcinoma (ESCC). A total of 200 lesions, including 120 invasive ESCC, 80 esophageal squamous intraepithelial neoplasia consisting of 40 low-grade intraepithelial neoplasia (LGIEN) and 40 high-grade intraepithelial neoplasia (HGIEN), as well as 20 confounding lesions, were examined by immunohistochemical (IHC) staining for GGCT. IHC staining for Ki-67 and p53 was also performed in esophageal squamous intraepithelial neoplasia to compare the diagnostic power of GGCT. Increased expression of GGCT was common in invasive ESCC and HGIEN (87.5% and 85.0%, respectively), but was much less frequently observed in LGIEN (17.5%). GGCT expression significantly correlated with the presence of lymph node metastasis and the degree of differentiation. In the differential diagnosis of LGIEN and HGIEN, GGCT possessed both high sensitivity and high specificity, while Ki-67 and p53 only possessed either high sensitivity or high spec...Continue Reading

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Citations

May 7, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Susumu KageyamaAkihiro Kawauchi
Nov 20, 2014·The Biochemical Journal·Gaofeng FanNicholas K Tonks
Sep 5, 2015·BioMed Research International·Susumu KageyamaAkihiro Kawauchi
May 6, 2015·Cancer Biotherapy & Radiopharmaceuticals·Zhifeng LinQiang Lin
Jul 5, 2016·Chemical & Pharmaceutical Bulletin·Hiromi IiJun'ichi Uenishi
Feb 16, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Taku YoshiyaTatsuhiro Yoshiki
Feb 5, 2015·Organic & Biomolecular Chemistry·Taku YoshiyaYuji Nishiuchi
Mar 7, 2021·Biochemical and Biophysical Research Communications·Hiromi IiSusumu Nakata

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