β-lactoglobulin stabilized nanemulsions--Formulation and process factors affecting droplet size and nanoemulsion stability

International Journal of Pharmaceutics
Ali AliFlorence Agnely

Abstract

To avoid the toxicological concerns associated to synthetic surfactants, proteins might be an alternative for the stabilization of pharmaceutical nanoemulsions. The present study investigates the use of β-lactoglobulin (β-lg) to stabilize oil in water biocompatible nanoemulsions intended for a pharmaceutical use and prepared by high pressure homogenization (HPH). The effects of composition (nature and weight fraction of oil, β-lg concentration) and of process parameters (pressure and number of cycles) on the droplet size and on the stability of nanoemulsions were thoroughly assessed. The nanoemulsions prepared with β-lg at 1 wt% and with 5 wt% Miglyol 812 (the oil with the lowest viscosity) displayed a relatively small particle size (about 200 nm) and a low polydispersity when a homogenization pressure of 100 MPa was applied for 4 cycles. These nanoemulsions were the most stable formulations over 30 days at least. Emulsification efficiency of β-lg was reduced at higher homogenization pressures (200 MPa and 300 MPa). The effect of HPH process on the interfacial properties of β-lg was evaluated by drop shape analysis. This treatment had an effect neither on the interfacial tension nor on the interfacial dilatational rheology of β...Continue Reading

References

Feb 1, 1991·International Journal of Biological Macromolecules·E Dickinson, Y Matsumura
Apr 1, 1970·Lipids·A A Spector, J E Fletcher
Nov 4, 2000·Biochimica Et Biophysica Acta·L Sawyer, G Kontopidis
Jul 11, 2003·Biomaterials·Béatrice HeurtaultJean-Pierre Benoit
Apr 10, 2004·Advances in Colloid and Interface Science·Tharwat TadrosC Solans
Aug 25, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Slavka TcholakovaThomas Danner
Jun 28, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·J BenjaminsE H Lucassen-Reynders
Aug 31, 2007·International Journal of Pharmaceutics·M El-Mahrab-RobertJ-L Grossiord
Apr 22, 2008·Advanced Drug Delivery Reviews·Michael J HawkinsNeil Desai
Sep 23, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Mirian M SakunoYasuki Matsumura
Oct 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Tim J WoosterPeerasak Sanguansri
Mar 9, 2010·Drug Discovery Today·Huabing ChenJinming Gao
Sep 3, 2010·Journal of Agricultural and Food Chemistry·Francesco DonsìGiovanna Ferrari
Dec 8, 2010·Journal of Agricultural and Food Chemistry·Sung Je LeeDavid Julian McClements
Dec 15, 2010·Journal of Colloid and Interface Science·Eléonore BouyerFlorence Agnely
Jun 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Jiali ZhaiMarie-Isabel Aguilar
Dec 31, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Prabhakar KandadiKishan Veerabrahma
Mar 16, 2012·Journal of Food Science·Patrick G MaherYrjö H Roos
Apr 20, 2012·Expert Opinion on Drug Delivery·Sabna KottaJaved Ali
Jun 12, 2012·Journal of Colloid and Interface Science·Baoru YinPing Yao
Jul 4, 2012·Journal of Agricultural and Food Chemistry·Rong LiangQingrong Huang
Feb 12, 2013·International Journal of Pharmaceutics·Wei HeWei Wu
Jun 26, 2013·Food Chemistry·Ricky S H Lam, Michael T Nickerson
Aug 19, 2014·Journal of Colloid and Interface Science·Benjamin ZeebJochen Weiss

❮ Previous
Next ❯

Citations

Jan 27, 2017·Annual Review of Food Science and Technology·David Julian McClementsCheryl Chung
Apr 18, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing LiZhisheng Wu
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qingqing LiuQin Wang
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana B SchreinerMaria Filomena Barreiro
Aug 11, 2018·IET Nanobiotechnology·Hamed HasssanzadehMahmoud Rezazad Bari
Oct 15, 2020·Advanced Healthcare Materials·Andrey S KlymchenkoNicolas Anton
Feb 1, 2021·Colloids and Surfaces. B, Biointerfaces·Ozgur Tarhan, Maria Julia Spotti
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Ilyes DammakCarlos Adam Conte-Junior
Oct 13, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Kate L ThompsonSteven P Armes
Dec 30, 2021·Journal of Cosmetic Dermatology·Rana Abu-HuwaijRania Hamed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.