δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) mediate intermittent hypoxia induced protection of canine myocardium

Basic Research in Cardiology
Juan A EstradaRobert T Mallet

Abstract

Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown. This study examined the contributions of DOR and ROS in mediating intermittent hypoxia-induced cardioprotection. Mongrel dogs completed a 20 day program consisting of 5-8 daily, 5-10 min cycles of moderate, normobaric hypoxia (FIO2 0.095-0.10), with intervening 4 min room air exposures. Subsets of dogs received the DOR antagonist naltrindole (200 μg/kg, sc) or antioxidant N-acetylcysteine (250 mg/kg, po) before each hypoxia session. Twenty-four hours after the last session, the left anterior descending coronary artery was occluded for 60 min and then reperfused for 5 h. Arrhythmias detected by electrocardiography were scored according to the Lambeth II conventions. Left ventricles were sectioned and stained with 2,3,5-triphenyl-tetrazolium-chloride, and infarct sizes were expressed as percentages of the area at risk (IS/AAR). Intermittent hypoxia sharply decreased IS/AAR from 41 ± 5 % (n = 12) to 1.8 ± 0.9 % (n =...Continue Reading

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Citations

Aug 9, 2016·Autonomic Neuroscience : Basic & Clinical·Juan A EstradaJames L Caffrey
Jan 1, 2019·Experimental Physiology·Justin D SprickCaroline A Rickards
Oct 8, 2019·High Altitude Medicine & Biology·Tetiana V SerebrovskaValeriy B Shatylo
Apr 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Robert T MalletH Fred Downey
May 18, 2016·Experimental Biology and Medicine·Eugenia B ManukhinaRobert T Mallet
Jun 18, 2021·Vascular Health and Risk Management·Robert T MalletMartin Burtscher

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