α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking

Proceedings of the National Academy of Sciences of the United States of America
Saskia HaegensOle Jensen

Abstract

Extensive work in humans using magneto- and electroencephalography strongly suggests that decreased oscillatory α-activity (8-14 Hz) facilitates processing in a given region, whereas increased α-activity serves to actively suppress irrelevant or interfering processing. However, little work has been done to understand how α-activity is linked to neuronal firing. Here, we simultaneously recorded local field potentials and spikes from somatosensory, premotor, and motor regions while a trained monkey performed a vibrotactile discrimination task. In the local field potentials we observed strong activity in the α-band, which decreased in the sensorimotor regions during the discrimination task. This α-power decrease predicted better discrimination performance. Furthermore, the α-oscillations demonstrated a rhythmic relation with the spiking, such that firing was highest at the trough of the α-cycle. Firing rates increased with a decrease in α-power. These findings suggest that α-oscillations exercise a strong inhibitory influence on both spike timing and firing rate. Thus, the pulsed inhibition by α-oscillations plays an important functional role in the extended sensorimotor system.

References

Apr 1, 1996·Electroencephalography and Clinical Neurophysiology·C M KrauseB Pörn
Nov 1, 1996·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·G PfurtschellerC Neuper
Jan 25, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Nicholas R CooperJohn H Gruzelier
Mar 4, 2003·Nature Reviews. Neuroscience·Ranulfo Romo, Emilio Salinas
May 22, 2003·Trends in Cognitive Sciences·Rufin VanRullen, Christof Koch
Dec 6, 2005·The European Journal of Neuroscience·P SausengN Birbaumer
Aug 5, 2006·Brain Research Reviews·W KlimeschS Hanslmayr
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregor ThutAlvaro Pascual-Leone
Feb 20, 2007·Trends in Neurosciences·Satu Palva, J Matias Palva
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel Jokisch, Ole Jensen
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Luis LemusRanulfo Romo
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·P FriesRobert Desimone
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anil BollimuntaMingzhou Ding
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Adrián HernándezRanulfo Romo
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle E MathewsonTony Ro
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Niko A BuschRufin VanRullen
Nov 1, 1977·Neuroscience Letters·F H Lopes Da Silva, W Storm Van Leeuwen
May 4, 2010·Neuron·Adrián HernándezRanulfo Romo
Aug 5, 2010·Journal of Cognitive Neuroscience·Barbara F HändelOle Jensen
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie R JonesChristopher I Moore
Nov 10, 2010·Frontiers in Human Neuroscience·Ali Mazaheri, Ole Jensen
Dec 2, 2010·Frontiers in Human Neuroscience·Ole Jensen, Ali Mazaheri
Jan 14, 2011·Journal of Neurophysiology·Ian C GouldAnna C Nobre
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jue MoMingzhou Ding
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Freek van EdeEric Maris
Feb 12, 2011·Neuroscience·K L Anderson, Mingzhou Ding
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·René ScheeringaAndreas Kleinschmidt
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anil BollimuntaMingzhou Ding
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saskia HaegensOle Jensen
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Saskia HaegensRanulfo Romo
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A BuffaloRobert Desimone

Citations

Jul 4, 2012·Nature Neuroscience·Bernhard P StaresinaRichard N Henson
Oct 15, 2013·Journal of Cognitive Neuroscience·Andrew Jaegle, Tony Ro
Apr 18, 2013·PloS One·Kristina LaaksonenNina Forss
Jul 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikael LundqvistAnders Lansner
Nov 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frédéric RouxPeter J Uhlhaas
May 24, 2013·Brain Topography·Thomas HartmannNathan Weisz
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nathan WeiszChristoph Braun
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Saskia HaegensRanulfo Romo
May 20, 2014·Trends in Neurosciences·Ole JensenMathilde Bonnefond
Apr 20, 2014·Journal of Cognitive Neuroscience·Maximilien Chaumon, Niko A Busch
Aug 15, 2013·Cognitive, Affective & Behavioral Neuroscience·Tzvetan PopovGregory A Miller
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sepideh SadaghianiAndreas Kleinschmidt
Feb 26, 2016·Frontiers in Psychology·Carola Salvi, Edward M Bowden
Sep 11, 2014·Proceedings of the National Academy of Sciences of the United States of America·Timo van KerkoerlePieter R Roelfsema
Jan 9, 2016·Cerebral Cortex·Diego A GutniskyValentin Dragoi
Dec 15, 2015·Cerebral Cortex·Kacie DoughertyAlexander Maier
Dec 8, 2015·Memory & Cognition·Tyler D BancroftPhilip Servos
Dec 17, 2014·Psychophysiology·Tzvetan PopovBrigitte Rockstroh
Aug 14, 2015·Psychonomic Bulletin & Review·Carola SalviMark Beeman
Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stephanie J KayserChristoph Kayser
Mar 17, 2015·Journal of Cognitive Neuroscience·Rosanne M van DiepenAli Mazaheri
Mar 19, 2014·Frontiers in Computational Neuroscience·Tyler D BancroftPhilip Servos
Jan 8, 2015·Frontiers in Human Neuroscience·Tomas RosPatrik Vuilleumier
Jun 7, 2014·Frontiers in Human Neuroscience·Antje StraußJonas Obleser
Jul 16, 2014·Frontiers in Systems Neuroscience·Jörn M HorschigAli Bahramisharif
Jul 6, 2014·Frontiers in Human Neuroscience·Verena N BuchholzW Pieter Medendorp
Dec 3, 2014·Trends in Neurosciences·Nicholas A KetzRandall C O'Reilly
May 31, 2016·Brain Stimulation·Christopher GundlachBernhard Sehm
May 27, 2016·Proceedings. Biological Sciences·Alessandro BenedettoM Concetta Morrone

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.