γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation

Mediators of Inflammation
Weixi ZhangChangchong Li

Abstract

T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. The aim of this study was to evaluate the effect of GSI on Th17 cell differentiation in a mouse model of allergic asthma. OVA was used to induce mouse asthma model in the presence and absence of GSI. GSI ameliorated the development of OVA-induced asthma, including suppressing airway inflammation responses and reducing the severity of clinical signs. GSI also significantly suppressed Th17-cell responses in spleen and reduced IL-17 levels in serum. These findings suggest that GSI directly regulates Th17 responses through a Notch signaling-dependent pathway in mouse model of allergic asthma, supporting the notion that GSI is a potential therapeutic agent for the treatment of allergic asthma.

References

May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·J Y ChoD H Broide
Nov 7, 2006·Respiratory Research·Dominique M A BullensJan L Ceuppens
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura McKinleyJay K Kolls
Feb 24, 2009·American Journal of Respiratory and Critical Care Medicine·Jin Hyun KangIl Yup Chung
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Wisam Al-RamliQutayba Hamid
Oct 22, 2009·International Archives of Allergy and Immunology·Yang ZhaoWei Guo
Feb 16, 2010·Immunity·Freddy RadtkeH Robson Macdonald
Jan 12, 2011·Circulation·Kisha PiggottCornelia M Weyand
Jun 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shilpa KeerthivasanBarbara A Osborne
Mar 31, 2012·Journal of Leukocyte Biology·Toshihiro ItoAkihiro Matsukawa
Oct 2, 2012·Nature Reviews. Drug Discovery·Pierre Miossec, Jay K Kolls
May 15, 2013·Nature Reviews. Immunology·Freddy RadtkeFabienne Tacchini-Cottier
Jul 19, 2013·Asian Pacific Journal of Allergy and Immunology·Kaiyan LiWeining Xiong
Sep 12, 2013·International Archives of Allergy and Immunology·Cristan HerbertRakesh K Kumar

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Citations

Jun 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lori M NealMichal A Olszewski
Oct 14, 2017·Molecular Pharmacology·Musaddique HussainXimei Wu
May 2, 2017·Frontiers in Immunology·Irma TindemansRudi W Hendriks
Jul 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L-L LiuJ Yang
Jul 20, 2019·International Journal of Molecular Sciences·Miao-Tzu HuangBor-Luen Chiang
Apr 30, 2021·Frontiers in Immunology·Panagiotis F ChristopoulosEirik Sundlisæter
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Frederick Allen, Ivan Maillard
Nov 6, 2018·International Archives of Allergy and Immunology·Wo-Er JiaoShi-Ming Chen

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Methods Mentioned

BETA
flow cytometry
electrophoresis

Software Mentioned

SPSS

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