α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome.

Science China. Life Sciences
Rui WangGuanghui Wang

Abstract

The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in Parkinson's disease (PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology.

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Citations

Oct 3, 2020·International Journal of Molecular Sciences·Rui WangHaigang Ren
Mar 30, 2021·Frontiers in Aging Neuroscience·Youcui WangJunxia Xie
Jun 26, 2021·Frontiers in Aging Neuroscience·Haigang RenGuanghui Wang

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Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

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