α-Synuclein expression is modulated at the translational level by iron

Neuroreport
Fabia FebbraroMarina Romero-Ramos

Abstract

Several studies have suggested an interaction between α-synuclein protein and iron in Parkinson's disease. The presence of iron together with α-synuclein in Lewy bodies, the increase of iron in the substantia nigra and the correlation between polymorphism of the several genes implicated in iron metabolism and Parkinson's disease, support a role for iron in the neurodegeneration. Analysis of post mortem brains revealed increased amount of insoluble α-synuclein protein despite unchanged/reduced levels of α-synuclein mRNA in Parkinson's disease. Interestingly, on the basis of the presence of a putative iron responsive element in the 5'-UTR, it has been suggested that there is a possible iron-dependent translational control of human α-synuclein mRNA. Considering the similarity between the sequences present in human α-synuclein mRNA and the ferritin iron responsive element, we postulated that iron deficiency would decrease the translation of α-synuclein mRNA. Here we used HEK293 cells treated with iron chelator deferoxamine or ferric ammonium citrate to verify the possible iron-dependent translational control of human α-synuclein biosynthesis. We show that the amount of polysome-associated endogenous human α-synuclein mRNA decreases...Continue Reading

References

Oct 1, 1991·Brain Research. Molecular Brain Research·L Maroteaux, R H Scheller
Oct 3, 1999·The Journal of Biological Chemistry·M HashimotoE Masliah
Feb 19, 2002·The Journal of Biological Chemistry·Natalie GoltsBenjamin Wolozin
Jul 26, 2002·Journal of Neurology·Claire BorieUNKNOWN French Parkinson's disease genetic study group
Jul 12, 2003·Blood·Brian D Schneider, Elizabeth A Leibold
Apr 24, 2004·Annals of the New York Academy of Sciences·Mario E GötzPeter Riederer
Feb 16, 2005·Brain Research. Molecular Brain Research·Sandra FernaeusTiit Land
Jul 20, 2006·Nature Chemical Biology·Tracey A Rouault

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Citations

Sep 21, 2013·Annual Review of Pharmacology and Toxicology·Samuel M Goldman
Oct 16, 2015·Molecular Neurobiology·Giorgio BiasiottoIsabella Zanella
Apr 2, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Petr DusekJan Aaseth
Oct 15, 2013·Neurobiology of Disease·Shannon L RhodesBeate Ritz
Jul 4, 2015·Neuron·Viachaslau Bernat, Matthew D Disney
Feb 5, 2013·Free Radical Biology & Medicine·Orly WeinrebTamar Amit
Sep 16, 2016·Journal of Molecular Neuroscience : MN·Xuling LiPeng Lei
Apr 5, 2018·Current Neurology and Neuroscience Reports·Jin-Sung ParkCarolyn M Sue
Oct 17, 2017·Nutritional Neuroscience·Jian HanKeith M Erikson
Aug 10, 2017·Reviews in the Neurosciences·Sotirios Apostolakis, Anna-Maria Kypraiou
Aug 2, 2018·CNS Drugs·Dilan Athauda, Thomas Foltynie
Aug 5, 2018·Journal of Cellular Physiology·Mingzhu TangLinxi Chen
Mar 24, 2016·F1000Research·Pan ChenMichael Aschner
Oct 5, 2019·Cellular and Molecular Neurobiology·Khalid Bashir DarShowkat Ahmad Ganie
Jan 30, 2018·Journal of Alzheimer's Disease : JAD·Christine KaindlstorferGregor K Wenning
Jan 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Peiyuan ZhangMatthew D Disney
Sep 26, 2020·Chemical Society Reviews·Samantha M MeyerMatthew D Disney
Oct 6, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I V LitvinenkoI D Poltavsky
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Dinendra L Abeyawardhane, Heather R Lucas
Jan 23, 2020·Acta neurologica Belgica·Subramaniam Mohana DeviVellingiri Balachandar
Apr 8, 2020·Frontiers in Pharmacology·Chu HanBo Li
Aug 21, 2020·Learning & Memory·Jack T Rogers, Catherine M Cahill
Feb 1, 2017·Frontiers in Neurology·Wenbin WanChunjiu Zhong
Feb 7, 2019·Frontiers in Neuroscience·Karina JoppePaul Lingor
Mar 6, 2019·Frontiers in Neuroscience·Chao LiuTuck Wah Soong
Jan 14, 2021·Scientific Reports·Gunther KletetschkaEva Svecova
Feb 4, 2021·The International Journal of Neuroscience·Thomas M Berry, Ahmed A Moustafa
Feb 20, 2021·Frontiers in Genetics·Xiangzhen WeiLifang Jin
May 26, 2017·Neurotoxicology·Souvarish SarkarArthi Kanthasamy
Jul 30, 2020·Progress in Neurobiology·Laura Mahoney-SánchezJean-Christophe Devedjian

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