α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism

Annals of Neurology
Anouke van RumundMarcel M Verbeek

Abstract

A reliable biomarker is needed for accurate and early differentiation between Parkinson disease and the various forms of atypical parkinsonism. We used a novel real-time quaking-induced conversion (RT-QuIC) assay to detect α-synuclein (α-syn) aggregates in cerebrospinal fluid (CSF) of 118 patients with parkinsonism of uncertain clinical etiology and 52 controls. Diagnostic accuracy to distinguish α-synucleinopathies from non-α-synucleinopathies and controls was 84% (sensitivity = 75%, specificity = 94%, area under the curve = 0.84, 95% confidence interval = 0.78-0.91, p < 0.0001, positive predictive value = 93%). CSF α-syn RT-QuIC could be a useful diagnostic tool to help clinicians differentiate α-synucleinopathies from other forms of parkinsonism when the clinical picture is uncertain. Ann Neurol 2019;85:777-781.

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Citations

Oct 11, 2019·Annals of Clinical and Translational Neurology·Matilde BongianniGianluigi Zanusso
Nov 24, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sireesha ManneAnumantha G Kanthasamy
Oct 30, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·David G CoughlinDavid J Irwin
May 14, 2020·The FEBS Journal·Patrícia I Santos, Tiago F Outeiro
Dec 8, 2019·The Journal of Applied Laboratory Medicine·Serena Singh, Mari L DeMarco
Jan 29, 2020·Translational Neurodegeneration·Niccolo CandeliseInga Zerr
Apr 24, 2020·Nature Reviews. Neurology·Nicholas J AshtonDag Aarsland
Sep 12, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Susanne A SchneiderRoy N Alcalay
Nov 1, 2020·International Journal of Molecular Sciences·Pablo GraciaNunilo Cremades
Dec 30, 2020·Annals of Clinical and Translational Neurology·Christina D OrrùByron Caughey
Jun 4, 2020·Parkinsonism & Related Disorders·David G Coughlin, Irene Litvan
Apr 4, 2021·Pathogens·Thi-Thu-Trang Dong, Katsuya Satoh
Apr 6, 2021·Journal of Parkinson's Disease·Kathrin Doppler
Apr 16, 2021·Brain : a Journal of Neurology·Ambra StefaniUNKNOWN SINBAR (Sleep Innsbruck Barcelona) group
Apr 25, 2021·Lancet Neurology·Eduardo TolosaWerner Poewe

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Methods Mentioned

BETA
Assay

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