γδ T Cells: Crosstalk Between Microbiota, Chronic Inflammation, and Colorectal Cancer

Frontiers in Immunology
Yunben YangFuming Qiu

Abstract

Increasing evidence suggests that intestinal microbiota dysbiosis and chronic inflammation contribute to colorectal cancer (CRC) development. γδ T cells represent a major innate immune cell population in the intestinal epithelium that is involved in the maintenance of gut homeostasis, inflammation regulation, and carcinogenesis. The important contributions of γδ T cells are (i) to perform a protective role in the context of barrier damage and pathogenic microorganism translocation; (ii) to exert either pro- or anti-inflammatory effects at different inflammatory stages; and (iii) to boost the crosstalk between immune cells and tumor microenvironment, inducing a cascade of suppressive immune responses. Understanding the crucial role of γδ T cells would enable us to manipulate these cells during the CRC sequence and improve the efficacy of tumor therapy.

References

Apr 1, 1996·The Journal of Experimental Medicine·M J MaeurerM T Lotze
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea GlatzelDieter Kabelitz
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yaping ChenRichard Boismenu
Feb 7, 2003·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Anja A KühlJörg C Hoffmann
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyoko Inagaki-OharaAkihiko Yoshimura
Dec 13, 2005·Current Opinion in Immunology·Willi K BornRebecca L O'Brien
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anisa S IsmailLora V Hooper
May 1, 2009·Nature Reviews. Gastroenterology & Hepatology·Linda A FeaginsStuart J Spechler
Aug 28, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Claire DevilderEmmanuel Scotet
Sep 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gopal Murugaiyan, Bhaskar Saha
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Mar 5, 2011·Digestive Diseases and Sciences·Juan Carlos Andreu-BallesterCarlos Peñarroja-Otero
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anisa S IsmailLora V Hooper
Mar 1, 2012·Trends in Immunology·Dalil HannaniLaurence Zitvogel
Oct 16, 2012·Cellular & Molecular Immunology·Jian ZhengWenwei Tu
Dec 26, 2012·Trends in Immunology·Yueh-hsiu ChienImmo Prinz
Jan 26, 2013·Nature Reviews. Immunology·Pierre Vantourout, Adrian Hayday
Aug 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neil E McCarthyAndrew J Stagg
Aug 15, 2013·Cancer Letters·Gerhard Rogler
Oct 5, 2013·Cellular and Molecular Life Sciences : CMLS·Christian PetersDaniela Wesch
Oct 18, 2013·Nature Reviews. Cancer·Robert F Schwabe, Christian Jobin
Nov 7, 2013·MBio·Joseph P ZackularPatrick D Schloss
Jan 7, 2014·Annual Review of Immunology·Yueh-hsiu ChienMarc Bonneville
Mar 19, 2014·Cell Host & Microbe·Cynthia L Sears, Wendy S Garrett
Aug 12, 2014·Cancer Prevention Research·Joseph P ZackularPatrick D Schloss
Aug 19, 2014·Frontiers in Immunology·Asif Amin DarShubhada Vivek Chiplunkar

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Citations

Jan 29, 2020·Journal of Leukocyte Biology·Sergio D Catz, Kenneth R McLeish
Jun 11, 2019·Expert Review of Clinical Pharmacology·Zhongguang Chen, Lili Jiang
May 16, 2020·Critical Reviews in Food Science and Nutrition·Aziz Homayouni RadAmin Abbasi
Dec 20, 2018·Immunology and Cell Biology·Jacques Miller
Apr 30, 2019·Frontiers in Immunology·Anna Maria MileoStefania Miccadei
Oct 1, 2020·Immunology and Cell Biology·Radha Pujari, Gautam Banerjee
Aug 12, 2020·Basic & Clinical Pharmacology & Toxicology·Simone S ValverdeOrlando V de Sousa
Feb 12, 2021·FEBS Letters·Haitham Hajjo, Naama Geva-Zatorsky
Jan 11, 2022·Immunologic Research·Moulay Yassine BelghaliSaadia Ba-M'hamed

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nucleotide exchange

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