γδ T cells modulate humoral immunity against Plasmodium berghei infection

Immunology
Shin-Ichi InoueFumie Kobayashi

Abstract

It is unclear whether γδ T cells are involved in humoral immunity against Plasmodium infection. Here, we show that B-cell-immunodeficient mice and γδ T-cell-deficient mice were incapable of protecting against Plasmodium berghei XAT parasites. γδ T-cell-deficient mice developed reduced levels of antigen-specific antibodies during the late phase of infection. The numbers of follicular helper T cells and germinal centre B cells in γδ T-cell-deficient mice were lower than in wild-type mice during the late phase of infection. Expression profiling of humoral immunity-related cytokines in γδ T cells showed that interleukin-21 (IL-21) and interferon-γ (IFN-γ) are increased during the early stage of infection. Furthermore, blockade of IL-21 and IFN-γ signalling during the early stage of infection led to reduction in follicular helper T cells and germinal centre B cells. γδ T-cell production of IL-21 and IFN-γ is crucial for the development and maintenance of follicular helper T cells and germinal centre B cells during the late phase of infection. Our data suggest that γδ T cells modulate humoral immunity against Plasmodium infection.

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Citations

Apr 4, 2019·Nature Reviews. Immunology·Samarchith P KurupJohn T Harty
Nov 9, 2018·Frontiers in Immunology·Kathleen W Dantzler, Prasanna Jagannathan
Sep 6, 2019·Clinical & Translational Immunology·Kathleen W DantzlerPrasanna Jagannathan
Dec 24, 2019·Frontiers in Cellular and Infection Microbiology·Shahram Solaymani-MohammadiSteven M Singer

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