γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Hideyuki Ujiie, Ethan M Shevach

Abstract

γδ T cells have been shown to have immunoregulatory functions in several experimental autoimmune models. A mutation of the Foxp3 gene leads to the absence of regulatory T cells (Tregs) and a fatal systemic autoimmune disease in scurfy mice. Transfer of scurfy lymphocytes to RAG deficient (RAG(-/-)) recipients reproduces the inflammatory phenotype of the scurfy donor, including hepatitis and pneumonitis. In this study, we show that TCRα(-/-) recipients, which lack αβ T cells but have γδ T cells and B cells, are significantly protected from the hepatitis and pneumonitis, but not the dermatitis, induced by adoptive transfer of scurfy lymphocytes. Cotransfer of γδ T cells, but not B cells, prevented hepatitis and pneumonitis in RAG(-/-) recipients of scurfy lymphocytes. γδ T cells in the TCRα(-/-) recipients of scurfy cells markedly expanded and expressed a highly activated (CD62L(lo)CD44(hi)) phenotype. The activated γδ T cells expressed high levels of CD39 and NKG2D on their cell surface. A high frequency of scurfy T cells in TCRα(-/-) recipients produced IL-10, suggesting that γδ T cells may enhance suppressor cytokine production from scurfy T cells in TCRα(-/-) recipients. This study indicates that γδ T cells may contribute to ...Continue Reading

References

Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W R DrobyskiJ Klein
Sep 27, 2002·American Journal of Reproductive Immunology : AJRI·Olga NagaevaLucia Mincheva-Nilsson
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene D Ponomarev, Bonnie N Dittel
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natasha R LockeLeonard C Harrison
Sep 16, 2006·Immunological Reviews·Ian N CrispeSherry Wuensch
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip L SimonianAndrew P Fontenot
May 16, 2007·The Journal of Experimental Medicine·Silvia DeaglioSimon C Robson
Jul 13, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yongyan ChenZhigang Tian
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jim KimSang-Mo Kang
Jun 12, 2008·European Journal of Immunology·Eva N HuterEthan M Shevach
Feb 12, 2010·The Journal of Investigative Dermatology·Eva N HuterEthan M Shevach
Jun 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weifeng HeZhinan Yin
Oct 19, 2010·Nature Immunology·Lauren W CollisonDario A A Vignali
Oct 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianlei HaoZhinan Yin
Oct 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Na ZhaoZhinan Yin
Jan 26, 2013·Nature Reviews. Immunology·Pierre Vantourout, Adrian Hayday
Mar 14, 2013·International Immunopharmacology·Dieter KabelitzHans-Heinrich Oberg
Apr 23, 2013·Trends in Molecular Medicine·Luca AntonioliGyörgy Haskó
Jun 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dongchun LiangDeming Sun
Jul 23, 2013·The Journal of Allergy and Clinical Immunology·Atsushi OtsukaKenji Kabashima
Nov 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Susanne AschermannFalk Nimmerjahn
Apr 10, 2014·Immunological Reviews·Kathleen M CandandoThomas F Tedder

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Citations

Mar 5, 2017·Immunological Reviews·Bertrand AllardJohn Stagg
May 31, 2017·Immunology·Min Cheng, Shilian Hu
Mar 10, 2018·Cellular and Molecular Life Sciences : CMLS·Christian PetersDaniela Wesch
Feb 15, 2018·Frontiers of Medicine·Xuefu Wang, Zhigang Tian
Jun 12, 2020·World Journal of Gastroenterology : WJG·Qi-Hui ZhouZhi Chen
Feb 20, 2019·Journal for Immunotherapy of Cancer·Cynthia PerezJose A Guevara-Patino
Sep 25, 2020·Journal of Virology·Oussama MezianeCecilia T Costiniuk
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Luiz Eduardo Baggio SavioMaria Serena Longhi
Apr 2, 2021·Frontiers in Microbiology·Jinpu YangFeng Ji

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