* The Impact of Age on Skeletal Muscle Progenitor Cell Survival and Fate After Injury

Tissue Engineering. Part C, Methods
Yu ZhouTracy Criswell

Abstract

Sarcopenia is defined as the loss of skeletal muscle mass and function due to age, and represents a major cause of disability in the elderly population. The contributing factors to the onset of sarcopenia are not well defined, but appear to involve age-dependent changes in both the tissue microenvironment and muscle progenitor cell (MPC) population. MPC transplantation has the potential to be a novel therapy for treatment of muscle dysfunction due to aging or injury, but has not shown significant clinical efficacy to date. The goal of this research was to use a rat model of skeletal muscle injury to examine the differential effects of age on MPC survival, differentiation, and tissue regeneration after transplantation. Fluorescently labeled MPCs, derived from young (YMPCs) and adult (AMPCs) donor rats, were transplanted in the injured tibialis anterior (TA) muscles of young, adult, and aged rats. Our results demonstrated that integration and maturation of YMPCs into mature myofibers were dependent on the age of the host microenvironment; whereas, the integration and maturation of AMPCs were less dependent on age and more dependent on intrinsic cellular changes. These data suggest that the age of both the host microenvironment an...Continue Reading

References

May 1, 1992·Muscle & Nerve·J HuardJ P Tremblay
Jun 1, 1989·The American Journal of Physiology·B M Carlson, J A Faulkner
Jan 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·F SabidoW N Duran
Sep 1, 1993·Neuromuscular Disorders : NMD·J P TremblayM Tremblay
Feb 19, 2002·Mechanisms of Ageing and Development·Jane M Taylor-JonesCharlotte A Peterson
Jul 29, 2003·Aging Cell·Osvaldo Delbono
Dec 4, 2003·Science·Irina M ConboyThomas A Rando
Oct 6, 2007·Stem Cell Reviews·Andrew S Brack, Thomas A Rando
Jan 8, 2008·Journal of Orthopaedic Trauma·Thomas J WaltersDavid G Baer
May 9, 2008·Aging Cell·Suchitra D Gopinath, Thomas A Rando
Jan 19, 2010·Nature Cell Biology·Aaron W B JoeFabio M V Rossi
May 28, 2010·Cell Cycle·Anuradha NatarajanFabio M V Rossi
Jun 15, 2011·Aging·Irina M ConboyMichael J Conboy
Dec 3, 2011·The American Journal of Pathology·Tracy L CriswellShay Soker
Mar 30, 2012·Advances in Experimental Medicine and Biology·Ana SánchezJavier García-Sancho
Apr 12, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Alicia N LyleW Robert Taylor
Aug 25, 2012·Current Opinion in Neurology·Francesco S Tedesco, Giulio Cossu
Oct 2, 2012·Nature·Joe V ChakkalakalAndrew S Brack
Sep 10, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Jaqueline de Souza, Carmem Gottfried
Jun 10, 2014·The American Journal of Pathology·Yu ZhouTracy Criswell
May 24, 2015·Cell Metabolism·Marc A EgermanDavid J Glass
Jul 4, 2015·Comprehensive Physiology·Nicolas A DumontMichael A Rudnicki
Aug 8, 2015·Nature Medicine·Helen M BlauAndrew T V Ho
Oct 23, 2015·Circulation Research·Tommaso PoggioliRichard T Lee
Jan 20, 2016·Skeletal Muscle·Andrew S Brack, Pura Muñoz-Cánoves
Dec 6, 2016·Nature·Susan Eliazer, Andrew S Brack
Dec 22, 2016·Journal of Cell Communication and Signaling·Osvaldo Contreras, Enrique Brandan
Apr 4, 2017·Aging Cell·Kristen M Stearns-ReiderFabrisia Ambrosio

❮ Previous
Next ❯

Citations

Nov 14, 2018·Cell and Tissue Research·Mohamed A A Mahdy
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aiping LuJohnny Huard

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation
PCR
Force measurements

Software Mentioned

GraphPad Prism
GraphPad
Adobe Photoshop
LabVIEW
Excel
ImageJ
IncuCyte

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.