γ-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates

American Journal of Physiology. Lung Cellular and Molecular Physiology
Hiam Abdala-ValenciaJoan M Cook-Mills

Abstract

γ-Tocopherol increases responses to allergen challenge in allergic adult mice, but it is not known whether γ-tocopherol regulates the development of allergic disease. Development of allergic disease often occurs early in life. In clinical studies and animal models, offspring of allergic mothers have increased responsiveness to allergen challenge. Therefore, we determined whether γ-tocopherol augments development of allergic responses in offspring of allergic female mice. Allergic female mice were supplemented with γ-tocopherol starting at mating. The pups from allergic mothers developed allergic lung responses, whereas pups from saline-treated mothers did not respond to allergen challenge. The γ-tocopherol supplementation of allergic female mice increased the numbers of eosinophils twofold in the pup bronchoalveolar lavage and lungs after allergen challenge. There was also about a twofold increase in pup lung CD11b(+) subsets of CD11c(+) dendritic cells and in numbers of these dendritic cells expressing the transcription factor IRF4. There was no change in several CD11b(-) dendritic cell subsets. Furthermore, maternal supplementation with γ-tocopherol increased the number of fetal liver CD11b(+)CD11c(+) dendritic cells twofold ...Continue Reading

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Citations

Nov 7, 2016·Free Radical Biology & Medicine·Francesco GalliNesrin Kartal Özer
Aug 19, 2017·Oxidative Medicine and Cellular Longevity·Gabriele PizzinoAlessandra Bitto
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Nov 6, 2018·Nutrients·Ga Young Lee, Sung Nim Han
Sep 26, 2020·Frontiers in Pharmacology·Astrid HogenkampLinette E M Willemsen
Nov 23, 2020·International Immunopharmacology·Mohammad-Hossein ShamsMozhgan Safari
Apr 29, 2020·The Journal of Allergy and Clinical Immunology·Rajesh KumarJoan M Cook-Mills
Aug 17, 2019·Journal of Autoimmunity·Ioannis MorianosGeorgina Xanthou
Aug 10, 2021·Frontiers in Allergy·Matthew T WalkerJoan M Cook-Mills

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