α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma

Biomolecules
Carolina Sánchez-RodríguezRicardo Sanz-Fernández

Abstract

The aim of this work is to study, in an in vitro head and neck squamous cell carcinomas model the anti-angiogenic and anti-migratory properties of self-assembled polymeric nanoparticles (NPs) with demonstrated selective anticancer activity. The NPs are based on α-tocopheryl succinate (α-TOS) encapsulated in the hydrophobic core of the NPs. We analyzed the effect of the newly synthetized α-TOS-loaded NPs in proliferating endothelial cells and hypopharynx carcinoma squamous cells and measured markers of angiogenesis, apoptosis and reactive oxygen species (ROS). α-TOS-loaded NPs suppressed angiogenesis by inducing accumulation of ROS and inducing apoptosis of proliferating endothelial cells. These NPs also decrease the number and quality of capillary-like tubes in an in vitro three-dimensional (3D) experiment, decrease the production of the pro-angiogenic vascular endothelial growth factor and down-regulate the expression of its receptor. The anti-migratory efficacy of α-TOS is corroborated in hypopharynx carcinoma cells by decreasing the secretion of matrix metalloproteases 2 and 9 (MMP-2 and MMP-9) and inhibiting cell migration. These results confirm that α-TOS-based NPs not only present anticancer properties, but also antiangio...Continue Reading

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Citations

Feb 6, 2019·International Journal of Molecular Sciences·Vaishali AggarwalMukerrem Betul Yerer
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Gan Huang, Shu-Ting Pan
Mar 7, 2021·Pharmaceutics·Gloria María Pontes-QueroBlanca Vázquez-Lasa

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Methods Mentioned

BETA
nanoprecipitation
dynamic light scattering
scanning
transmission
atomic force microscopy
Assay
enzyme-linked immunosorbent assay

Software Mentioned

TScratch
AlphaFaseFC
CSElab
Origin
ImageJ

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