δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

Lipids in Health and Disease
Asaf A QureshiNilofer Qureshi

Abstract

δ-Tocotrienol is a naturally occurring proteasome inhibitor, which has the capacity to inhibit proliferation and induce apoptosis in several cancer cells obtained from several organs of humans, and other cancer cell lines. Moreover, results of plasma total mRNAs after δ-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-α, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-γ after post-treatment. This down-regulation of proteasome subunits leads to autophagy, apoptosis of immune cells and several genes. The present study describes RNA-sequence analysis of plasma total mRNAs obtained from δ-tocotrienol treatment of hepatitis C patients on gene expression regulated by proteasome. Pooled specimens of plasma total mRNAs of pre-dose versus post-dose of δ-tocotrienol treatment of hepatitis C patients were submitted to RNA-sequence analyses. The data based on > 1 and 8-fold expression changes of 2136 genes were uploaded into "Ingenuity Pathway Analyses (IPA)" for core analysis, which describes possible canonical pathways, upstream regulators, diseases and functional metabolic networks. The IPA of "molecules" indicated fold change in...Continue Reading

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Citations

Jan 18, 2019·Recent Patents on Anti-cancer Drug Discovery·Fabrizio FontanaPatrizia Limonta
Jun 20, 2020·The Korean Journal of Internal Medicine·Kyoung-Woon KimHae-Rim Kim
Jun 26, 2020·Journal of Agricultural and Food Chemistry·Hong SunHao Song

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Methods Mentioned

BETA
PCR
RNA-Seq
nucleotide exchange
ubiquitination

Software Mentioned

Ingenuity
Ingenuity Pathway Analyses ( IPA )
IPA
Ingenuity Knowledge Base
Ingenuity Pathway Analysis ( IPA )
Ingenuity Pathway Analysis

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