γ-Tubulin complexes in microtubule nucleation and beyond

Molecular Biology of the Cell
Berl OakleyY Zheng

Abstract

Tremendous progress has been made in understanding the functions of γ-tubulin and, in particular, its role in microtubule nucleation since the publication of its discovery in 1989. The structure of γ-tubulin has been determined, and the components of γ-tubulin complexes have been identified. Significant progress in understanding the structure of the γ-tubulin ring complex and its components has led to a persuasive model for how these complexes nucleate microtubule assembly. At the same time, data have accumulated that γ-tubulin has important but less well understood functions that are not simply a consequence of its function in microtubule nucleation. These include roles in the regulation of plus-end microtubule dynamics, gene regulation, and mitotic and cell cycle regulation. Finally, evidence is emerging that γ-tubulin mutations or alterations of γ-tubulin expression play an important role in certain types of cancer and in other diseases.

References

Aug 1, 1986·Molecular and Cellular Biology·C F WeilB R Oakley
Feb 9, 2000·Current Biology : CB·A KhodjakovC L Rieder
Jan 3, 2001·The Journal of Cell Biology·R N GunawardaneY Zheng
Aug 22, 2001·Molecular Biology of the Cell·T W HendricksonH C Joshi
Apr 16, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Leah VardyTakashi Toda
Jan 9, 2003·Current Opinion in Cell Biology·Didier JobBerl Oakley
Dec 12, 2003·Molecular Biology of the Cell·Natalie L PrigozhinaBerl R Oakley
Sep 16, 2004·Molecular and Cellular Biology·Lea M StaritaJeffrey D Parvin
Mar 18, 2005·Molecular Biology of the Cell·Sabina Zimmerman, Fred Chang
May 18, 2005·Oncogene·Claire LescaMartine Defais
Jun 15, 2006·Journal of Neuropathology and Experimental Neurology·Christos D KatsetosPavel Dráber
Aug 11, 2006·Molecular Biology of the Cell·Lara CuschieriJackie Vogel
Dec 16, 2006·Journal of Cellular Biochemistry·Suisheng ZhangFrank Grosse
Apr 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Luke M RiceDavid A Agard
Apr 18, 2008·Cell Cycle·Adrianna S RodriguezJanet L Paluh
Apr 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryota UeharaGohta Goshima
Dec 2, 2009·The Journal of Cell Biology·Anaïs BouissouBrigitte Raynaud-Messina
Dec 17, 2009·Cancer Biology & Therapy·Edward H ChoStuart S Martin
Aug 4, 2010·The Journal of Cell Biology·Tania NayakBerl R Oakley
Apr 6, 2011·Journal of Cellular Physiology·Barbora HořejšíPavel Dráber
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yoshikazu JohmuraKyung S Lee
Jul 5, 2011·Nature Structural & Molecular Biology·Valérie GuilletLionel Mourey
Jul 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Greta HöögMaria Alvarado-Kristensson
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sabine PetryRonald D Vale
Sep 29, 2011·Biochemical and Biophysical Research Communications·Thomas HubertJan Gettemans
Oct 14, 2011·Nature Reviews. Molecular Cell Biology·Justin M KollmanDavid A Agard
Mar 13, 2012·The Plant Journal : for Cell and Molecular Biology·Masayoshi NakamuraTakashi Hashimoto
Apr 12, 2012·The Journal of Biological Chemistry·Åsa EhlénMaria Alvarado-Kristensson

❮ Previous
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Citations

Nov 12, 2015·Journal of Molecular Biology·Nicole Monroe, Christopher P Hill
Dec 26, 2015·Current Biology : CB·Gerald Schatten, Tim Stearns
Dec 1, 2015·Frontiers in Neuroscience·Anna A W M Sanders, Irina Kaverina
Jun 22, 2016·The Journal of Cell Biology·Paul T Conduit
Oct 26, 2016·Brain Research Bulletin·Andrew J Matamoros, Peter W Baas
Jun 16, 2017·Journal of Cell Science·Noriyoshi YagiTakashi Hashimoto
Sep 7, 2016·Gene Regulation and Systems Biology·Anu ChackoSonya M Marshall-Gradisnik
Mar 17, 2018·Journal of Glaucoma·Audrey M BernsteinJose M Wolosin
Jun 16, 2017·Endocrine-related Cancer·Shivangi Agarwal, Dileep Varma
Nov 15, 2018·Molecular Biology of the Cell·Juan ShenChuanhai Fu
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Oier Etxebeste, Eduardo A Espeso
Jan 26, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eduarda DráberováPavel Dráber
May 2, 2018·The Journal of Cell Biology·Kan YaguchiRyota Uehara
Sep 13, 2018·Cellular and Molecular Life Sciences : CMLS·Susan E LaFlammeBethsaida Nieves
Mar 28, 2018·AIMS Genetics·Yekaterina ZvorykinaIvan Vorobjev
Oct 28, 2019·Cells·Pavla Binarová, Jack Tuszynski
Dec 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Huiying MiaoBo Liu
Jan 12, 2017·Protoplasma·Vadym SulimenkoPavel Dráber
Aug 26, 2018·Scientific Reports·Calvin SimerlyGerald Schatten
Nov 16, 2020·Current Opinion in Cell Biology·Peng LiuElmar Schiebel
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Gaël MénaschéUlrich Blank
May 19, 2021·Developmental Biology·Delia RicoloSofia J Araújo
Jun 16, 2021·Microbiological Research·Francisco Alejandro Lagunas-RangelRosa María Bermúdez-Cruz
Oct 6, 2021·Nature Communications·Hao LiuXiumin Yan
Jul 4, 2017·Current Biology : CB·Jieyan V ChenTimothy L Megraw

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