1 -Antitrypsin deficiency: a variant with no detectable 1 -antitrypsin

R C TalamoS Makino


No alpha(1)-antitrypsin could be detected in the serum of a 24-year-old man with advanced pulmonary emphysema by agarose electrophoresis, immnuno-electrophoresis, double diffusion in agarose gel, or alpha(1)-antitrypsin genetic typing by a combination of starch-gel electrophoresis and crossed antigen-antibody electrophoresis. A circulating alpha(1)-antitrypsin inactivator could not be demonstrated. Evidence was obtained in family members of genetic transmission of this new alpha(1)-antitrypsin variant.


Nov 2, 1977·Human Genetics·P ArnaudR Creyssel
Jan 1, 1980·Human Genetics·P Pongpaew, F P Schelp
Nov 6, 1975·Humangenetik·J P MartinC Ropartz
Jun 1, 1974·Biochemical Genetics·V E Headings, S Bose
Jun 15, 2007·Lung·Alan T MulgrewN Gerry McElvaney
Oct 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·L E Lie-injo
Nov 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·M J KahnH L Frank
Dec 1, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·E C KlasenR R Frants
Nov 24, 1973·Lancet·L M PachmanD Giacomoni
Aug 17, 1974·Lancet·A Forabosco, B Dallapiccola
Aug 17, 1974·Lancet·G BlundellB Bradley
Jun 10, 1976·The New England Journal of Medicine·T Sveger
Nov 9, 1978·The New England Journal of Medicine·J O Morse
Jan 31, 1980·The New England Journal of Medicine·J M HoodT E Starzl
Nov 1, 1974·Acta paediatrica Scandinavica·C B LaurellC G Ljunggren
Jul 1, 1974·Gut·P W Brunt
Aug 1, 1975·Journal of Clinical Pathology·E C Sweeney
Dec 1, 1989·The American Review of Respiratory Disease·M HolmesR G Crystal
May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·Jasvir S ParmarDavid A Lomas
Nov 1, 1989·American Journal of Respiratory Cell and Molecular Biology·R N SifersS L Woo
Apr 15, 1976·Human Genetics·J J Hoffmann, W G van den Broek
Nov 27, 2014·Orphanet Journal of Rare Diseases·Ilaria FerrarottiMaurizio Luisetti
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·R D Feld
Jan 1, 1977·Scandinavian Journal of Gastroenterology·C Larsson, S Eriksson
Sep 1, 1982·The American Journal of the Medical Sciences·H D Allende, F V Ona
Oct 1, 1976·Chest·L F Black
Apr 15, 1977·European Journal of Biochemistry·A Hercz, M Barton
Jun 24, 1988·The American Journal of Medicine·M BrantlyR G Crystal
Nov 1, 1980·Current Problems in Pediatrics·J S Latimer, H L Sharp
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F K Ghishan, H L Greene
Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H Perlmutter
Nov 1, 1993·Journal of Gastroenterology and Hepatology·A ShahidM A Waqar

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