1, 3β-Glucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy

Carbohydrate Polymers
Pankaj K SinghSurajit Karmakar

Abstract

Recurrence of glioblastoma is one of the major concerns due to its heterogeneous nature and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery of chemotherapeutic agent targeting both cancer and glioma stem cells could provide a solution to recurrent malignancies of the glioblastoma tumor. The approach described here provides enhanced chemotherapeutic potency utilizing 1,3β-Glucan as an outer shell to the chitosan nanoparticles (Cs-NPs) loaded with paclitaxel to prevent hemolysis with, the core-shell nano-structure (Cs-PTX-NP) enabling effective chemotherapy against malignant glioblastoma. The prepared nanoparticles (1,3β-Cs-PTX-NPs) with sustained release of the paclitaxel provide a targeted therapeutic approach that overcome systemic toxicities with the 1,3β-Glucan shell and improve drug bioavailability. Hemolysis investigation indicated that 1,3β-Cs-PTX-NP was significantly less hemolytic than paclitaxel enabling intravenous delivery. Also, 1,3β-Cs-PTX-NPs were considerably more cytotoxic (IC50) against glioma cancer LN18 cells and C6 stem-like cells compared with the PTX. In conclusion, this study found that 1,3β-Cs-PTX-NP addressed serious limitation with systemic delivery of paclitaxe...Continue Reading

Citations

Sep 13, 2018·Current Stem Cell Research & Therapy·Shabnam MohebbiMasoud Mozafari
Sep 24, 2019·Scandinavian Journal of Immunology·Vaclav VetvickaPetr Sima
Jan 23, 2020·Cancers·Edouard Alphandéry
Sep 24, 2019·Future Medicinal Chemistry·Raul OrtizJose Prados
Dec 5, 2020·International Journal of Biological Macromolecules·Masoumeh EslahiBahman Yousefi
Dec 25, 2019·International Journal of Biological Macromolecules·Milad AshrafizadehVijay Kumar Thakur
Dec 31, 2020·Cancers·Elia BozzatoVéronique Préat
Aug 22, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Monika NehraAjeet Kaushik
Dec 5, 2021·AAPS PharmSciTech·Nkafu Bechem NdemazieEdward Agyare

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