1-(4-Amino-2-hydroxyphenyl)ethanone from Phomopsis liquidambari showed quorum sensing inhibitory activity against Pseudomonas aeruginosa.

Applied Microbiology and Biotechnology
Jin-Wei ZhouEn-Qi Liu

Abstract

Phomopsis liquidambari S47 is an endophytic fungus isolated from the leaves of Punica granatum. Here, we are the first to report a quorum sensing (QS) inhibitor 1-(4-amino-2-hydroxyphenyl)ethanone (AHE) isolated and identified from the metabolites of P. liquidambari S47. Exposure to AHE at sub-MIC concentrations notably suppressed the secretion of acyl-homoserine lactones and virulence factors in Pseudomonas aeruginosa PAO1. To investigate the metabolic variations of P. aeruginosa PAO1 exposed to AHE, magnetic resonance imaging-based metabolomic analysis was performed. AHE treatment created a disturbance in the QS system by suppressing the expressions of QS-related genes. The disturbed QS system resulted in the inhibited activity of antioxidant enzymes and thus enhanced oxidative stress. The vegetable infection assay showed that the virulence of P. aeroginosa PAO1 was attenuated which could be due to the impacts to the amino acid and nucleotide metabolism by enhanced oxidative stress. These findings suggest that AHE has a potential to become an antivirulence "agent" to tackle P. aeruginosa infection. KEY POINTS: • AHE treatment inhibited AHL secretion and virulence factors production. • AHE treatment aggravated oxidative stress...Continue Reading

References

Jul 1, 1990·Stroke; a Journal of Cerebral Circulation·J W Schmidley
Sep 7, 2001·Annual Review of Microbiology·M B Miller, B L Bassler
Mar 1, 2006·International Journal of Medical Microbiology : IJMM·Karin HeurlierDieter Haas
Jan 30, 2007·Journal of Agricultural and Food Chemistry·Armando M PominiAnita J Marsaioli
Mar 10, 2007·Neurochemistry International·Maja L JohansenHelle S Waagepetersen
Oct 29, 2008·Medicinal Research Reviews·Nanting NiBinghe Wang
Apr 15, 2009·Antimicrobial Agents and Chemotherapy·Liang YangTim Tolker-Nielsen
Sep 14, 2011·Journal of Natural Products·Yee Meng ChongKok-Gan Chan
Nov 23, 2013·Food Chemistry·Issac Abraham Sybiya Vasantha PackiavathyArumugam Veera Ravi
Dec 12, 2013·Chemical Communications : Chem Comm·Aviad MandabiMichael M Meijler
Sep 25, 2014·Protein & Cell·Jasmine Lee, Lianhui Zhang
Oct 11, 2015·Bioorganic & Medicinal Chemistry Letters·Ji-Yang ShengAi-Qun Jia
Dec 8, 2015·Applied Biochemistry and Biotechnology·Muhammad Javid IqbalAmer Jamil
Jan 23, 2018·Journal of Agricultural and Food Chemistry·Jin-Wei ZhouAi-Qun Jia
Aug 22, 2018·Applied Microbiology and Biotechnology·Jin-Wei ZhouAi-Qun Jia
Jan 5, 2019·Journal of Agricultural and Food Chemistry·Jin-Wei ZhouAi-Qun Jia
Jun 5, 2019·Applied Microbiology and Biotechnology·Jin-Wei ZhouAi-Qun Jia
Sep 19, 2019·Current Medicinal Chemistry·Elena AncheevaPeter Proksch

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
PCA

Software Mentioned

OSC
SPSS
PLS
DA
MOE
Dock

Related Concepts

Related Feeds

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Brandon ChanParvin Mousavi
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Dazhi JiangChenfeng Peng
Clinical Neurology and Neurosurgery
Frank JonkerErik Scherder
© 2021 Meta ULC. All rights reserved