PMID: 4287164Jun 24, 1966Paper

1-Adamantanamine hydrochloride: inhibition of Rous and Esh Sarcoma viruses in cell culture

Science
A M WallbankN G Klinikowski

Abstract

I-Adamantanamine hydrochloride, added to chick embryo cells, inhibited focus production upon subsequent inoculation of the cells with Rous and Esh sarcoma viruses. Addition of the chemical to suspensions of Rous and Esh viruses before they were added to chick cell cultures did not inactivate the viruses; and the addition to chick cells did not prevent plaque formation following their inoculation with Newcastle disease virus. This indicates that cells treated with 1-adamantanamine hydrochloride are capable of supporting viral replication, and these observations suggest that the drug inhibits growth of two oncogenic viruses by prevention of virus penetration, but not by a virucidal effect or cell intoxication.

References

Jan 1, 1965·Advances in Virus Research·P K Vogt
Jan 1, 1965·Archiv für die gesamte Virusforschung·J S Oxford, G C Schild
May 15, 1964·Science·W L DAVIESC E HOFFMANN
Sep 25, 1964·Science·H F MAASSAB, K W COCHRAN
Jun 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·E M NEUMAYERC E HOFFMAN
Sep 1, 1965·Journal of Bacteriology·C E HoffmannR A Goldsby

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Citations

May 1, 1983·Quarterly Reviews of Biophysics·J WhiteA Helenius
Feb 1, 1980·The Journal of Cell Biology·A HeleniusE Fries
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Ana Ferle-VidovićLidija Vuković
Mar 1, 1967·Postgraduate Medical Journal·H A Reimann
Feb 1, 1983·Virology·K B Andersen, B A Nexø
Jun 1, 1973·Bacteriological Reviews·S Dales
Oct 1, 1990·Journal of Virology·J M GilbertJ M White

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