1% alendronate gel as local drug delivery in the treatment of Class II furcation defects: a randomized controlled clinical trial

Journal of Periodontology
Avani R PradeepS B Naik

Abstract

Alendronate (ALN), an aminobisphosphonate, is known to stimulate the formation of osteoblast precursors to promote osteoblastogenesis. The present study aims to explore the efficacy of 1% ALN gel as a local drug delivery system in adjunct to scaling and root planing (SRP) for the treatment of Class II furcation defects in comparison with placebo gel. A total of 69 mandibular Class II furcation defects were randomized and treated with either 1% ALN gel or placebo gel. Clinical parameters were recorded at baseline, 3 months, 6 months, and 12 months, and radiographic parameters were recorded at baseline, 6 months, and 12 months. Defect fill at baseline, 6 months, and 12 months was calculated on standardized radiographs using image analysis software. Mean probing depth (PD) reduction and mean relative vertical (RVCAL) and horizontal (RHCAL) clinical attachment level gain were shown to be greater in the ALN group than the placebo group at 3, 6, and 12 months. Furthermore, a significantly greater mean percentage of bone fill was found in the ALN group (32.11% ± 6.18%, 32.66% ± 5.86%), compared with the placebo group (2.71% ± 0.61%, 1.83% ± 1.51%), at 6 and 12 months, respectively. The results of the present study show that local deli...Continue Reading

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Citations

Jul 10, 2014·Drug Delivery·Deeksha JoshiGoutam Rath
May 3, 2016·The Journal of Evidence-based Dental Practice·Satheesh ElangovanVeerasathpurush Allareddy
Sep 26, 2014·International Journal of Dentistry·Lars Rasmusson, Jahan Abtahi
May 13, 2017·British Dental Journal·N P ShahC Sproat
Apr 23, 2019·European Journal of Orthodontics·Vasileios F ZymperdikasMoschos A Papadopoulos
Nov 20, 2020·Journal of Dental Research·V F ZymperdikasM A Papadopoulos
Feb 2, 2021·Journal of Medicinal Chemistry·Jéssica S BarbosaSusana Santos Braga
Feb 5, 2021·Journal of Oral Biology and Craniofacial Research·Francisco Wilker Mustafa Gomes MunizThiago Marchi Martins
Sep 5, 2021·The Journal of Evidence-based Dental Practice·Kumar KcManash Shrestha

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