1-Alkenyl group of ethanolamine plasmalogen derives mainly from de novo-synthesized fatty alcohol within peroxisomes, but not extraperoxisomal fatty alcohol or fatty acid

Journal of Biochemistry
H Hayashi, M Hara

Abstract

The origin of the 1-alkenyl group of ethanolamine plasmalogen was investigated. Three candidates were examined for the fatty alcohol forming the 1-alkenyl group. [1-(14)C]Hexadecanoic acid, [1-(14)C]hexadecanol, or [1-(14)C]lignoceric acid was administered to rats treated with 0.25% clofibrate-chow for 2 weeks. At 0.5, 1, 2, 3, and 4 h after administration of the radiolabeled compound, rats were killed and ethanolamine-containing phosphoglyceride (EPG)-rich fraction was isolated from the liver. The components of the 1-radyl group in EPG-rich fraction were separated and the radioactivity was determined. The radiolabel after administration of [1-(14)C]hexadecanoic acid or [1-(14)C]hexadecanol was almost wholly incorporated into diacyl-type glycerophosphoethanolamine (GPE), and was predominantly found in hexadecanoic acid fraction. Therefore, the long-chain fatty acid may be incorporated intact into the diacyl groups, and the long-chain fatty alcohol may be similarly incorporated after oxidation to the acid. In contrast, the radiolabel after the administration of [1-(14)C]lignoceric acid was found in the 1-alkenyl group of ethanolamine plasmalogen. After hydrolysis of the 1-alkenyl group by treatment of the plasmalogen with HCl va...Continue Reading

Citations

Mar 29, 2001·Progress in Lipid Research·N Nagan, R A Zoeller
Oct 8, 1998·Experimental Gerontology·T Brosche, D Platt
Sep 30, 2000·European Journal of Biochemistry·F WagnerU Zähringer
Jun 19, 2010·Journal of Lipid Research·Paul P Van Veldhoven
Jun 11, 2008·Journal of Neurochemistry·Mushfiquddin KhanInderjit Singh
Jul 18, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Elodie PasturalDayan B Goodenowe

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