PMID: 9177871Jun 1, 1997Paper

1-alpha-Hydroxyvitamin D3 treatment decreases bone turnover and modulates calcium-regulating hormones in early postmenopausal women

Bone
J T ChenE Ogata

Abstract

50 Japanese women within 10 years after menopause (mean age 52.5 years) were studied to determine the effects of 0.75 microgram of 1-alpha-hydroxyvitamin D3 [1-alpha-(OH)D3] with calcium (150 mg/day) (treated group: N = 25) and calcium only (control group: N = 25) for 12 months on bone mass and metabolism. Their L2-4 BMD measurements were 1.5 SD below the mean value of Japanese young, normal women. L2-4 BMDs increased significantly in the treated group (+2.1%; p < 0.01), but decreased significantly in controls (-2.1%; p < 0.01). Although serum calcium and creatinine remained unchanged in both groups, phosphorus levels increased significantly in the treated group (p < 0.01). Urinary calcium/creatinine (Cr) increased in both groups. Urinary pyridinoline/Cr and deoxypyridinoline/Cr decreased significantly in the treated group (p < 0.05), but not in the control group. Serum osteocalcin levels remained unchanged in both groups. Intact parathyroid hormone levels decreased significantly (p < 0.05) and calcitonin levels significantly increased in the treated group (p < 0.05), but these changes were not observed in the control group. These data clearly demonstrate that 0.75 microgram of 1-alpha-(OH)D3 maintained bone mass by reducing bo...Continue Reading

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Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T Nakamura
Jun 28, 2005·Aging Clinical and Experimental Research·Florent RichyJean-Yves Reginster
Aug 7, 2002·European Journal of Pharmacology·Kyoko TeramuraKoichiro Takahashi
Aug 7, 2004·Journal of Periodontology·Charles F HildeboltRoberto Civitelli
Sep 21, 2005·Journal of Periodontology·Charles F Hildebolt
Nov 19, 2011·Clinical Oral Implants Research·Hsiang-Hsi HongChee-Jen Chang
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masahiko SatoYanfei L Ma
Jan 10, 2003·Journal of Cellular Biochemistry·B Lawrence Riggs
Mar 11, 2015·Journal of Cellular and Molecular Medicine·Hsiang-Hsi HongTing-An Chou
Oct 3, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Toshiyuki YasuiMinoru Irahara
Dec 18, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Jun IwamotoMitsuyoshi Uzawa
Sep 19, 2009·Maturitas·Debbie L Hay, David R Poyner
Jun 23, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F Massart
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Apr 15, 2014·The Cochrane Database of Systematic Reviews·Alison AvenellDianne O'Connell
Nov 12, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Agnieszka BrodowskaJolanta Nawrocka-Rutkowska

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