1-Amino-2'-fucosyllactose inhibits biofilm formation by Streptococcus agalactiae

The Journal of Antibiotics
Kelly M Craft, Steven D Townsend

Abstract

2'-Fucosyllactose (2'-FL) is a ubiquitous oligosaccharide in human milk. Importantly, this carbohydrate promotes the growth of several strains of Bifidobacteria, a class of beneficial gut commensal, and inhibits epithelial binding of pathogens. In light of these protective effects, we elected to evaluate the potential of 2'-FL to serve as an antibacterial agent against Group B Streptococcus (GBS). While 2'-FL was devoid of any substantial antimicrobial or antibiofilm activity, conversion of 2'-FL to its reducing end β-amine provided a novel antibiofilm compound.

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Citations

Sep 12, 2019·Open Biology·Rebecca E Moore, Steven D Townsend
Jun 21, 2020·Nutrients·Mostafa AsadpoorSaskia Braber
Sep 12, 2020·Critical Reviews in Food Science and Nutrition·Emmanuel Pérez-EscalanteLuis Guillermo González-Olivares
Jul 24, 2021·Journal of the American Chemical Society·Lianyan L Xu, Steven D Townsend

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Methods Mentioned

BETA
NMR

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