β1-and β2-adrenoceptors in hippocampal CA3 region are required for long-term memory consolidation in rats

Brain Research
Jian ZhengBaoming Li

Abstract

The existence of β-adrenoceptors (ARs) in the hippocampus and the importance of β-ARs in regulating synaptic plasticity and learning/memory function are well documented. As known, β-ARs in area cornu ammonis 1 (CA1) are involved in regulating memory consolidation. However, little is known about the functional roles of the β-ARs subtypes, β1- and β2-ARs, in the hippocampal cornu ammonis 3 (CA3) region. To address this question, we firstly locally infused the β1- or β2-ARs antagonist into the CA3 region and observed that blockage of either β1-AR or β2-AR impaired long-term contextual fear memory and water-maze spatial memory. We also found that, following the contextual fear conditioning, the expression of β1-AR in the CA3 region significantly increased, whereas β2-AR was unchanged. Then intra-CA3 infusion of recombinant lentiviral RNAi vectors for β1 or β2-ARs also produced deficit in contextual memory consolidation. Taken together, the results suggested that the β1- and β2-ARs in the CA3 region were involved in hippocampus dependent memory consolidation.

References

Aug 1, 1978·The Journal of Comparative Neurology·J H FallonR Y Moore
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·G E HandelmannC J Cummins
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J F Guzowski, J L McGaugh
Jun 21, 1997·Annals of the New York Academy of Sciences·B RoozendaalJ L McGaugh
Apr 8, 1998·Annual Review of Neuroscience·A J SilvaS Kida
May 23, 1998·Annual Review of Pharmacology and Toxicology·D K Rohrer, B K Kobilka
Jan 15, 2000·Science·J L McGaugh
Dec 12, 2001·Brain & Development·K Kobayashi, T Kobayashi
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hill-Aina SteffenachMay-Britt Moser
May 7, 2002·Neurobiology of Learning and Memory·Henry YinJohn G Csernansky
Jun 1, 2002·Science·Kazu NakazawaSusumu Tonegawa
Aug 17, 2002·Trends in Neurosciences·James L McGaugh
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
May 20, 2003·The European Journal of Neuroscience·Jin-Zhao JiBao-Ming Li
Apr 22, 2004·Nature Reviews. Neuroscience·Kazu NakazawaSusumu Tonegawa
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Jul 6, 2004·The European Journal of Neuroscience·Stéphanie DaumasJean-Michel Lassalle
Sep 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicola J BroadbentRobert E Clark
Feb 4, 2006·Behavioural Brain Research·Paul E Gilbert, Raymond P Kesner

❮ Previous
Next ❯

Citations

Apr 10, 2018·The FEBS Journal·Robert ZorecAlexei Verkhratsky
May 30, 2019·Frontiers in Cellular Neuroscience·Nicholas ChaayaSelena E Bartlett
Mar 30, 2017·Frontiers in Behavioral Neuroscience·Huiwen ZhuXing Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.