PMID: 7542369Feb 1, 1995Paper

1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices

Neuropharmacology
M A DesaiD D Schoepp

Abstract

It is now clear that the AMPA subtype of ionotropic glutamate receptors (iGluRs) undergoes a rapid desensitization in response to activation by AMPA receptor agonists. This desensitization is inhibited by compounds such as aniracetam and cyclothiazide, which act at a distinct site on the AMPA receptor complex. In particular, cyclothiazide greatly potentiates AMPA receptor-mediated depolarizing responses in the hippocampus. We have recently shown cyclothiazide also increases AMPA-induced release of [3H]norepinephrine ([3H]NE). More, recently, a benzamide compound, 1-(1,3-benzodioxol-5-ylcarbonyl)-piperidine (1-BCP), has been reported to enhance AMPA-induced currents and to facilitate memory retention in rats in a number of memory tasks. In this study, the effects of 1-BCP on excitatory amino acid agonist-induced [3H]NE release in rat hippocampal slices were determined. We report that 1-BCP, like cyclothiazide, selectively potentiates AMPA-induced [3H]NE release. However, cyclothiazide was more potent and efficacious than 1-BCP. Nevertheless, these data suggest a role for AMPA receptor-mediated enhancement of norepinephrine release as a mechanism of action for nootropic compounds such as 1-BCP.

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Citations

Jan 15, 1999·Molecular Neurobiology·K K Dev, J M Henley
Aug 2, 2002·European Journal of Pharmacology·Trevor W Stone, Jonas I Addae
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
Dec 1, 1996·The Journal of Pharmacy and Pharmacology·P GarofaloF Makovec
Feb 9, 2000·Neuropharmacology·J L Cotton, K M Partin

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