1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity

Biochemical and Biophysical Research Communications
Carlos A BuenoAndrea A Barquero

Abstract

The 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), isolated from extracts of Melia azedarach L., displays antiviral and immunomodulating properties. CDM is the first reported tetranortriterpenoid responsible for the alkalinization of intracellular compartments affecting both, viral endocytic and exocytic pathways. Considering that viral glycoprotein synthesis is completely dependent upon cellular membrane trafficking, we questioned whether CDM might also interfere with the normal transport of cellular glycoproteins. This study demonstrates that CDM promoted a transient block in the transport of two cellular glycoproteins, the transferrin receptor (TfR) and TNF-alpha. Nevertheless, CDM did not affect the transferrin binding ability of TfR and did not impede the TNF-alpha secretion. On the other hand, CDM disturbed the intracellular localization of capsid, glycoprotein and tegument proteins simultaneously in the same HSV-1 infected cells. Besides, we show that concanamycin A and monensin provoke a permanent blockage of viral and cellular glycoproteins, in contrast to the delay observed after CDM treatment. Thus, the delay on glycoprotein transport caused by CDM would account for the strong inhibition on virus multiplication without...Continue Reading

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Citations

Sep 8, 2011·Chemical Reviews·Qin-Gang Tan, Xiao-Dong Luo
Sep 18, 2012·Biochemical and Biophysical Research Communications·María Eugenia DávolaAndrea A Barquero
Dec 22, 2014·Medical Microbiology and Immunology·Carlos Alberto BuenoLaura Edith Alché
Sep 26, 2012·Microvascular Research·Carlos A BuenoLaura E Alché
Aug 31, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikoletta G NtalliPierluigi Caboni
Oct 12, 2010·Journal of Agricultural and Food Chemistry·Nikoletta G NtalliPierluigi Caboni

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