1 H-NMR metabolomics response to a realistic diet contamination with the mycotoxin deoxynivalenol: Effect of probiotics supplementation

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Imourana Alassane-KpembiIsabelle P Oswald

Abstract

Low-level contamination of food and feed by deoxynivalenol (DON) is unavoidable. We investigated the effects of subclinical treatment with DON, and supplementation with probiotic yeast Saccharomyces cerevisiae boulardii I1079 as a preventive strategy in piglets. Thirty-six animals were randomly assigned to either a control diet, a diet contaminated with DON (3 mg/kg), a diet supplemented with yeast (4 × 109 CFU/kg), or a DON-contaminated diet supplemented with yeast, for four weeks. Plasma and tissue samples were collected for biochemical analysis,1H-NMR untargeted metabolomics, and histology. DON induced no significant modifications in biochemical parameters. However, lesion scores were higher and metabolomics highlighted alterations of amino acid and 2-oxocarboxylic acid metabolism. Administering yeast affected aminoacyl-tRNA synthesis and amino acid and glycerophospholipid metabolism. Yeast supplementation of piglets exposed to DON prevented histological alterations, and partial least square discriminant analysis emphasised similarity between the metabolic profiles of their plasma and that of the control group. The effect on liver metabolome remained marginal, indicating that the toxicity of the mycotoxin was not eliminated....Continue Reading

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Citations

Mar 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ana Paula F L BracarenseIsabelle P Oswald
Mar 20, 2021·Analytica Chimica Acta·M Hernández-MesaG Dervilly
Aug 5, 2021·Critical Reviews in Food Science and Nutrition·Haonan RuanMeihua Yang
Sep 15, 2021·Critical Reviews in Food Science and Nutrition·Silu HouYaxian Yan

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