1-Hydroxyethylidene-1,1-bisphosphonate (HEBP) simultaneously induces two distinct types of hypomineralization in the rat incisor dentine

Calcified Tissue International
Y OgawaT Yagi

Abstract

Effects of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on the dentinogenesis of the rat maxillary incisor were microradiographically examined 96 hours after a single subcutaneous injection. HEBP produced hypomineralized incremental bands in the enamel (HPOe) and in the dentine (outer HPO1 and inner HPO2) in a dose-dependent manner. In the labial dentine, both HPO1 and HPO2 did not extend apically beyond the apical limit of the HPOe and were thus located in the circumpulpal dentine. The two lesions in the labial dentine fully developed with a dosage of 10 mg/ P/kg or larger, and with 15 mg P/kg or larger, gross hypoplastic lesions developed. Therefore, histological analysis at shorter postinjection intervals was carried out on the labial dentine with 10 mg P/kg of HEBP. The HPO1 appeared along the dentine-predentine junction by 24 hours and was characterized by reduced numbers of inorganic crystals and 10 nm particles which invested the collagen fibrils. Therefore, the HPO1 was judged to be produced by the disturbance of transformation of the predentine to dentine. The precursor lesion of HPO2 appeared in the proximal predentine by 4 hours, and was characterized by reduced number of collagen fibrils and unusually coarse interf...Continue Reading

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Citations

Jan 1, 1995·Connective Tissue Research·C BrandstenL Hammarström
Feb 20, 2016·Environmental Toxicology and Pharmacology·Ana Prates SoaresAlexandre Ribeiro do Espírito Santo
Sep 4, 2010·International Endodontic Journal·B CviklR Gruber
Feb 8, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Luciana F MassaVictor E Arana-Chavez
Apr 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A J MouleK F Adkins
Mar 12, 1998·Endocrine Reviews·H Fleisch
Feb 1, 1996·Acta Odontologica Scandinavica·I Alatli, L Hammarström

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