β1 integrin: an emerging player in the modulation of tumorigenesis and response to therapy.

Cell Adhesion & Migration
Grant A Howe, Christina L Addison

Abstract

Historically, a hallmark of tumorigenesis was the ability to grow in an anchorage-independent manner. Hence, tumors were thought to proliferate and survive independently of integrin attachment to the substratum. However, recent data suggest that integrins regulate not only tumor cell proliferation, survival and migration, but may also influence their response to anti-cancer agents. Interestingly, these influences are largely masked by growth of tumor cells in the standard, yet artificial, environment of 2D cell culture, but are readily apparent under 3D in vitro culture conditions and in tumor growth in vivo. We, and others, have recently demonstrated that the β1 integrin subunit controls the growth and invasion of prostate tumor cells in 3D culture conditions. Recently, the importance of integrins has also been demonstrated using tissue specific conditional knockout strategies in transgenic mouse tumor models, where they control primary tumor growth and dictate the site of metastatic spread. Furthermore, integrin-extracellular matrix interactions may modulate the response of tumors to standard chemotherapy agents or radiation. Taken together, these results highlight the important role of integrins in regulating tumor growth an...Continue Reading

References

Jun 1, 1995·Seminars in Cancer Biology·A Lochter, M J Bissell
Oct 1, 1994·Journal of Cutaneous Pathology·H Tuominen, M Kallioinen
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·C M WitkowskiA E Cress
Sep 1, 1995·Cancer Metastasis Reviews·A E CressR B Nagle
Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·B B TysnesR Bjerkvig
Apr 1, 1997·Current Opinion in Cell Biology·J T Parsons, S J Parsons
Feb 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S J MurantN J Maitland
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·D M RamosR Pytela
Oct 29, 1998·The Journal of Surgical Research·Y C JangF F Isik
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A MasumotoM Otsuki
Jun 4, 1999·Progress in Biophysics and Molecular Biology·D D SchlaepferD J Sieg
Mar 27, 2002·Clinical Science·Robert C Rintoul, Tariq Sethi
May 22, 2002·International Journal of Radiation Biology·N CordesD Van Beuningen
Dec 23, 2003·Journal of Cellular Biochemistry·Ray B Nagle
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tobias N DechowJacqueline F Bromberg
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Mar 31, 2007·Nature Methods·Genee Y LeeMina J Bissell
Jun 19, 2007·Molecular Cancer Therapeutics·Ronald P C WongGang Li
Jul 13, 2007·Seminars in Cell & Developmental Biology·Agnès NoëlErik Maquoi
Nov 17, 2007·Cancer Research·Jyotsnabaran HalderAnil K Sood
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hicham LahlouWilliam J Muller
Mar 15, 2008·Cancer Research·Walter Gregory RobertsFelix Vajdos

❮ Previous
Next ❯

Citations

Sep 12, 2015·International Journal of Cancer. Journal International Du Cancer·Miriam WidderLutz P Müller
Dec 5, 2015·Frontiers in Pharmacology·Anne-Florence BlandinMonique Dontenwill
Jul 31, 2012·Experimental Cell Research·Louisa C E WindusVicky M Avery
Nov 1, 2016·Irish Journal of Medical Science·D S HeffernanAlfred Ayala
Mar 2, 2016·Molecular and Cellular Biology·Erik HedrickStephen Safe
Aug 9, 2019·Current Molecular Medicine·Dmitry Olegovich BazhenovDmitry Igorevich Sokolov
Jun 20, 2015·PloS One·Nazanin RuppenderHung-Ming Lam
Apr 2, 2020·Cancer Metastasis Reviews·Rosalyn C Zimmermann, Danny R Welch
Aug 2, 2020·Breast Cancer Research : BCR·Kelsey F RuudWeimin Li
Jul 9, 2020·Scientific Reports·Arthur BrannonMarina Pasca di Magliano
Jun 23, 2019·Cells·Jeannette HuamanOlorunseun O Ogunwobi
Nov 15, 2020·Nanomaterials·Indra Van ZundertSusana Rocha
Jul 3, 2021·International Journal of Molecular Sciences·Milene N O MoritzJulie A Rhoades Sterling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.