1-Isopropylamino-3-(4-indanoxy)-2-propanol HC1: a potent beta-adrenoreceptor antagonist

British Journal of Pharmacology
B Levy, M Wasserman

Abstract

1. The beta-adrenoceptor blocking activity of 1-isopropylamino-3-(4-indanoxy)-2-propanol HCl (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea-pig tracheal strip.2. USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 mug/kg and higher. On the basis of comparative pA(2) values, USVC 6524 is approximately 10 times more potent as a beta-adrenoceptor antagonist than propranolol.3. Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong beta-adrenoceptor blockade.4. USVC 6524 also blocked beta-adrenoceptors in the isolated rat uterus and guinea-pig tracheal spiral strip.

References

Feb 10, 1967·Annals of the New York Academy of Sciences·J R Blinks
Feb 1, 1969·European Journal of Pharmacology·B Levy, B E Wilkenfeld
Apr 1, 1966·The American Journal of Physiology·J Nakano, T Kusakari
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
May 16, 1964·Lancet·J W BLACKA C DORNHORST
Jun 1, 1948·The American Journal of Physiology·R P AHLQUIST

Related Concepts

Adrenergic beta-Antagonists
Metazoa
Canis familiaris
Cavia porcellus
Heart
Indenes
Novodrin
Pavatym
Sympatholytic Effect
Trachea

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