PMID: 3754599Jan 1, 1986Paper

1-Methyl-1,4-androstadiene-3,17-dione (SH 489): characterization of an irreversible inhibitor of estrogen biosynthesis

Journal of Steroid Biochemistry
D HendersonU Kerb

Abstract

1-Methyl-1,4-androstadiene-3,17-dione (SH 489) was characterized as a competitive and irreversible inhibitor of human placental aromatase. The compound and the principal predicted metabolites show no endocrinological side effects suggesting that SH 489 should be suitable as a prototype drug for treatment of estrogen-dependent disease states.

Citations

Jan 1, 1994·Breast Cancer Research and Treatment·R W Brueggemeier
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