1-n-Hexadecyl-3-methylimidazolium methanesulfonate and chloride salts with effective activities against Candida tropicalis biofilms

Letters in Applied Microbiology
V Z BergamoA M Fuentefria

Abstract

Although the use of catheters in critically ill patients is mostly inevitable, this invasive procedure comes together with several health risks. Within this context, the contamination with Candida tropicalis is a primary concern as this highly prevalent pathogenic yeast can develop an extensive polymeric matrix that hinders the drugs' penetration and its effective treatment. This study addresses the potential for the 1-n-hexadecyl-3-methylimidazolium methanesulfonate (C16 MImMeS) and chloride (C16 MImCl) salts for eliminating the viable cells of biofilms of Candida tropicalis, compared to the performance of chlorhexidine (CHX) and fluconazole (FLZ). The minimum concentration required of C16 MImMeS, C16 MImCl, CHX and FLZ for elimination of the biofilm's viable cells (MBEC) was evaluated through microtitre plate biofilm exposure with different concentrations of these substances. These concentrations were determined at 80% of effective activity against the biofilm's viable cells by using the MTT reduction assay. C16 MImMeS and C16 MImCl were able to eliminate the viable cells at much lower concentrations (15·6 and 0·45 μg ml(-1) respectively) than CHX (1250 μg ml(-1) ) and FLZ (resistance of the viable cells). This demonstrates t...Continue Reading

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Citations

Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Juliana MarioniMaría Gabriela Paraje
Nov 4, 2016·Journal of Applied Microbiology·V Z BergamoA M Fuentefria
Jul 15, 2020·Mycoses·Magda Antunes de ChavesAlexandre Meneghello Fuentefria
Dec 2, 2017·Pest Management Science·Emanuelle GoellnerOnilda Santos da Silva
May 7, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Alexandre EhrhardtAlexandre Meneghello Fuentefria
Aug 6, 2018·International Immunopharmacology·Raísha Costa MartinsPedro Roosevelt Torres Romão

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