1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

Angewandte Chemie
Alexander A KirichokPavel K Mykhailiuk

Abstract

The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their validation in drug discovery.

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Citations

Jan 18, 2018·Chemistry : a European Journal·Alexander A KirichokPavel K Mykhailiuk
Aug 2, 2018·Organic & Biomolecular Chemistry·Worawat NiwetmarinTimothy Gallagher
Mar 21, 2019·Chemical Communications : Chem Comm·Leleti Rajender ReddySharadsrikar Kotturi
Apr 13, 2019·Organic & Biomolecular Chemistry·Valeriia Hutskalova, Pavel K Mykhailiuk
Feb 16, 2020·Angewandte Chemie·Vadym V LevterovPavel K Mykhailiuk
Jul 13, 2018·Chemical Science·Dimitri F J CaputoEdward A Anderson
Nov 20, 2020·The Journal of Organic Chemistry·Valeriya ShcherbakovaPavel K Mykhailiuk
Mar 24, 2021·Angewandte Chemie·Jasper L TylerVarinder K Aggarwal
May 4, 2021·RSC Medicinal Chemistry·Matthias R BauerBenjamin C Whitehurst
Jul 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jin-Xin ZhaoPhil S Baran
Dec 1, 2017·The Journal of Organic Chemistry·Alpa K PancholiMichael Shipman
Aug 25, 2021·The Journal of Organic Chemistry·Vladimir I SavychPavel K Mykhailiuk
Oct 12, 2019·Organic Letters·Dmitry DibchakPavel K Mykhailiuk
Aug 16, 2017·The Journal of Organic Chemistry·Aleksandr V DenisenkoPavel K Mykhailiuk
Mar 13, 2018·The Journal of Organic Chemistry·Yevhen A SkalenkoPavel K Mykhailiuk
Sep 16, 2021·Organic Letters·Luis NóvoaMariola Tortosa
Nov 23, 2021·Journal of Medicinal Chemistry·Ying WangAnil Vasudevan

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