1 Versus 2-cm Excision Margins for pT2-pT4 Primary Cutaneous Melanoma (MelMarT): A Feasibility Study

Annals of Surgical Oncology
Marc D MoncrieffMichael A Henderson

Abstract

There is a lack of consensus regarding optimal surgical excision margins for primary cutaneous melanoma > 1 mm in Breslow thickness (BT). A narrower surgical margin is expected to be associated with lower morbidity, improved quality of life (QoL), and reduced cost. We report the results of a pilot international study (MelMarT) comparing a 1 versus 2-cm surgical margin for patients with primary melanoma > 1 mm in BT. This phase III, multicentre trial [NCT02385214] administered by the Australia & New Zealand Medical Trials Group (ANZMTG 03.12) randomised patients with a primary cutaneous melanoma > 1 mm in BT to a 1 versus 2-cm wide excision margin to be performed with sentinel lymph node biopsy. Surgical closure technique was at the discretion of the treating surgeon. Patients' QoL was measured (FACT-M questionnaire) at baseline, 3, 6, and 12 months after randomisation. Between January 2015 and June 2016, 400 patients were randomised from 17 centres in 5 countries. A total of 377 patients were available for analysis. Primary melanomas were located on the trunk (56.9%), extremities (35.6%), and head and neck (7.4%). More patients in the 2-cm margin group required reconstruction (34.9 vs. 13.6%; p < 0.0001). There was an increased...Continue Reading

References

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Citations

Dec 21, 2019·Current Oncology Reports·Alessandro A E TestoriAlexander C J van Akkooi
Apr 3, 2020·Annals of the Royal College of Surgeons of England·K L LauS Rannan-Eliya
Apr 28, 2019·Current Oncology Reports·Alberto Falk DelgadoAnna Falk Delgado
Sep 29, 2019·Annals of Surgical Oncology·C V AngelesG Karakousis
Jan 20, 2021·Head & Neck·Ryan P GoepfertJeffrey E Gershenwald
Mar 17, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sarah HannaRobyn Pm Saw

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT02385214

Software Mentioned

MelMarT

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