10-100 eV Ar+ ion induced damage to D-ribose and 2-deoxy-D-ribose molecules in condensed phase

Physical Chemistry Chemical Physics : PCCP
Ilko BaldMichael A Huels

Abstract

We report that 10-100 eV Ar+ ion irradiation induces severe damage to the biologically relevant sugar molecules D-ribose and 2-deoxy-D-ribose in the condensed phase on a polycrystalline Pt substrate. Ar+ ions with kinetic energies down to 15 eV induce effective decomposition of both sugar molecules, leading to the desorption of abundant cation and anion fragments, including CH3+, C2H3+, C3H3+, H3O+, CHO+, CH3O+, C2H3O+, H-, O-, and OH-, etc. Use of isotopically labelled molecules (5- 13C D-ribose and 1-D D-ribose) reveals the site specificity for some of the fragment origins, and thus the nature of the chemical bond breaking. It is found that all of the chemical bonds in both molecules are vulnerable to ion impact at energies down to 15 eV, particularly both the endo- and exocyclic C-O bonds. In addition to molecular fragmentation, several chemical reactions are also observed. A small amount of O-/O fragments abstract hydrogen to form OH-. It is found that the formation of the H3O+ ion is related to the hydroxyl groups of the sugar molecules, and is associated with additional hydrogen loss from the parent or adjacent molecules via hydrogen abstraction or proton transfer. The formation of several other cation fragments also requ...Continue Reading

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Citations

Oct 16, 2007·The Journal of Chemical Physics·Zongwu DengMichael A Huels
Feb 12, 2015·The Journal of Chemical Physics·Joong-Won Shin, Elliot R Bernstein
Mar 21, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Gemma Vall-LloseraElisabeth Rachlew
May 21, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Fresia AlvaradoThomas Schlathölter
Aug 16, 2006·Physical Review Letters·Zongwu DengMichael A Huels
Jan 8, 2015·The Journal of Physical Chemistry. a·Tomasz J Wasowicz, Bogusław Pranszke

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