10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

Biochemical and Biophysical Research Communications
Tsuyoshi GotoTeruo Kawada

Abstract

Our previous study has shown that gut lactic acid bacteria generate various kinds of fatty acids from polyunsaturated fatty acids such as linoleic acid (LA). In this study, we investigated the effects of LA and LA-derived fatty acids on the activation of peroxisome proliferator-activated receptors (PPARs) which regulate whole-body energy metabolism. None of the fatty acids activated PPARδ, whereas almost all activated PPARα in luciferase assays. Two fatty acids potently activated PPARγ, a master regulator of adipocyte differentiation, with 10-oxo-12(Z)-octadecenoic acid (KetoA) having the most potency. In 3T3-L1 cells, KetoA induced adipocyte differentiation via the activation of PPARγ, and increased adiponectin production and insulin-stimulated glucose uptake. These findings suggest that fatty acids, including KetoA, generated in gut by lactic acid bacteria may be involved in the regulation of host energy metabolism.

References

Jan 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Philippe GervoisBart Staels
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Buck S SamuelJeffrey I Gordon
Mar 1, 2011·Trends in Endocrinology and Metabolism : TEM·Thomas Greiner, Fredrik Bäckhed
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ikuo KimuraGozoh Tsujimoto
Aug 10, 2011·Nature Reviews. Endocrinology·Nathalie M DelzennePatrice D Cani
Jan 29, 2013·Cell Metabolism·Toshimasa Yamauchi, Takashi Kadowaki
Mar 9, 2013·Molecular Nutrition & Food Research·Tsuyoshi GotoSatoshi Nagaoka
Oct 9, 2013·Nature Medicine·Matthew Harms, Patrick Seale
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shigenobu KishinoJun Ogawa
Dec 24, 2013·Progress in Lipid Research·Manabu T NakamuraJuan J Loor
Jun 14, 2014·Biochimica Et Biophysica Acta·Takafumi HaraAkira Hirasawa

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Citations

Dec 4, 2015·European Journal of Pharmacology·Rachel Marion-LetellierSubrata Ghosh
Aug 8, 2018·Stress : the International Journal on the Biology of Stress·Jenny HadréviAnna Sjörs
Feb 17, 2019·Journal of Cellular Biochemistry·Parvaneh SeiriMohammad Soukhtanloo
Jul 30, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Minji KimTsuyoshi Goto
Sep 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ryuji Ohue-KitanoTeruo Kawada
Nov 11, 2019·Reviews in Endocrine & Metabolic Disorders·Marc Schoeler, Robert Caesar
Jul 28, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Katsuya MoritoTamotsu Tanaka
May 14, 2021·The Journal of Nutrition·Botao WangGang Wang
Jun 26, 2021·World Journal of Diabetes·Hye Rim Jang, Hui-Young Lee

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