Nov 3, 2009

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

Lancet
W C KnowlerDavid M Nathan

Abstract

In the 2.8 years of the Diabetes Prevention Program (DPP) randomised clinical trial, diabetes incidence in high-risk adults was reduced by 58% with intensive lifestyle intervention and by 31% with metformin, compared with placebo. We investigated the persistence of these effects in the long term. All active DPP participants were eligible for continued follow-up. 2766 of 3150 (88%) enrolled for a median additional follow-up of 5.7 years (IQR 5.5-5.8). 910 participants were from the lifestyle, 924 from the metformin, and 932 were from the original placebo groups. On the basis of the benefits from the intensive lifestyle intervention in the DPP, all three groups were offered group-implemented lifestyle intervention. Metformin treatment was continued in the original metformin group (850 mg twice daily as tolerated), with participants unmasked to assignment, and the original lifestyle intervention group was offered additional lifestyle support. The primary outcome was development of diabetes according to American Diabetes Association criteria. Analysis was by intention-to-treat. This study is registered with ClinicalTrials.gov, number NCT00038727. During the 10.0-year (IQR 9.0-10.5) follow-up since randomisation to DPP, the original...Continue Reading

  • References26
  • Citations851

References

  • References26
  • Citations851

Citations

Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Diastolic Blood Pressure Measurement
Glucose Metabolism Disorders
Metformin
Disorders of Sex Development
Cardiovascular Diseases
Impaired Glucose Tolerance
Prevention Program
Gestational Diabetes
Risk Reduction

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