10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors

BMC Geriatrics
Lauren C TindaleAngela R Brooks-Wilson

Abstract

Super-Seniors are healthy, long-lived individuals who were recruited at age 85 years or older with no history of cancer, cardiovascular disease, diabetes, dementia, or major pulmonary disease. In a 10-year follow-up, we aimed to determine whether surviving Super-Seniors showed compression of morbidity, and to test whether the allele frequencies of longevity-associated variants in APOE and FOXO3 were more extreme in such long-term survivors. Super-Seniors who survived and were contactable were re-interviewed 10 years after initial characterization. Health and lifestyle were characterized via questionnaire. Geriatric tests including the Timed Up and Go (TUG), Geriatric Depression Scale (GDS), Instrumental Activities of Daily Living (IADL) and the Mini-Mental State Exam (MMSE) were administered, and data were compared to results from on average 10 years earlier. As well, genotype and allele frequencies for SNPs rs7412 and rs429358 in APOE, and rs2802292 in FOXO3 were compared to the frequencies in the original collection of Super-Seniors and mid-life controls. Of the 480 Super-Seniors recruited from 2004 to 2007, 13 were alive, contactable, and consented to re-interview (mean age = 100.1 ± 3.3). Eight of these 13 participants (62%...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G B FrisoniM Trabucchi
Jul 27, 2001·Mechanisms of Ageing and Development·I M ReaUNKNOWN MONICA group (Belfast). Monitoring of Cardiovascular trends study group
May 19, 2006·Nature Reviews. Genetics·Kaare ChristensenJames W Vaupel
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kaare ChristensenJames W Vaupel
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bradley J WillcoxJ David Curb
Nov 4, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Linda G MarcMartha L Bruce
Nov 29, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D Craig WillcoxMakoto Suzuki
Aug 15, 2009·PloS One·Julius Halaschek-WienerAngela R Brooks-Wilson
Apr 15, 2010·Current Pharmaceutical Design·E BennatiI M Rea
Dec 1, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Heather E Wheeler, Stuart K Kim
Jan 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stacy L AndersenThomas T Perls
Apr 14, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joanne M MurabitoKathryn L Lunetta
Oct 9, 2012·Neurobiology of Aging·Nicole SchupfRichard Mayeux
Feb 2, 2013·Epidemiologic Reviews·Anne B Newman, Joanne M Murabito
Aug 9, 2013·Human Genetics·Angela R Brooks-Wilson
Feb 7, 2015·Scandinavian Cardiovascular Journal : SCJ·Lars WilhelmsenKurt Svärdsudd
Mar 2, 2016·Mechanisms of Ageing and Development·Seungjin RyuYousin Suh
Apr 23, 2016·Journal of Epidemiology and Community Health·Hiram Beltrán-SánchezS V Subramanian
Jun 21, 2016·Journal of the American Geriatrics Society·Jason L SandersAnne B Newman
Jul 6, 2016·Journal of the American Geriatrics Society·Khadija IsmailSofiya Milman
Apr 20, 2017·Journal of the American Geriatrics Society·Raya Elfadel KheirbekMaria D Llorente
Nov 7, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Paul GellertDagmar Dräger
May 26, 2018·PloS One·Julius Halaschek-WienerAngela R Brooks-Wilson

❮ Previous
Next ❯

Citations

Mar 19, 2020·Experimental Biology and Medicine·Renato de L VitorassoHenrique T Moriya
Apr 1, 2021·Current Treatment Options in Neurology·Candace Borders, Seyed Ahmad Sajjadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.