10-year follow-up results of the prospective, double-blinded, randomized, controlled study on autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of the femoral head.

Stem Cell Research & Therapy
Mengyuan LiQiujian Zheng

Abstract

Avascular necrosis of the femoral head (ANFH) is a severely disabling disease of the hip. Several clinical trials have shown promising outcomes on the use of mesenchymal stem cells for the treatment of ANFH, but long-term clinical assessments are lacking. Previously, we reported the 2-year follow-up results of a prospective, double-blinded, randomized, controlled study on autologous bone marrow buffy coat grafting combined with core decompression in patients with ANFH. Here, we report the 10-year follow-up results of this study. We recruited 43 (53 hips) patients from 2009 to 2010. The hips were randomly allocated to code decompression (CD) with or without bone marrow buffy coat (BBC) grafting. Participants underwent follow-up at 24, 60, and 120 months postoperatively. The visual analogue scale (VAS), Lequesne algofunctional index, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) osteoarthritis scores were recorded. Survival rate analysis and prognostic factor analysis were performed. The endpoint was defined as progression to Ficat stage IV or conversion to hip arthroplasty. A total of 31 patients (41 hips) were included in the final analysis. The CD + BBC group had better subjective assessment scores than...Continue Reading

References

Jun 3, 2004·The Journal of Bone and Joint Surgery. American Volume·Valérie GangjiMicheline Lambermont
Apr 29, 2008·Experimental Cell Research·Valerie D RoobrouckCatherine M Verfaillie
Apr 11, 2012·Journal of Tissue Engineering and Regenerative Medicine·Stefan LandgraeberWojciech Kowalczyk
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Sep 15, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jun YingHongting Jin
Apr 14, 2020·The Journal of Bone and Joint Surgery. American Volume·Michael A MontLynne C Jones

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Citations

May 9, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Octavian AndronicPatrick O Zingg

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Methods Mentioned

BETA
total hip arthroplasty
X-ray

Clinical Trials Mentioned

NCT01613612

Software Mentioned

SPSS

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