PMID: 8969929Nov 1, 1996Paper

11 beta-Hydroxylase activity in glucocorticoid suppressible hyperaldosteronism: lessons for essential hypertension?

Endocrine Research
J M ConnellR Fraser

Abstract

Corticosteroid 11 beta-hydroxylation is catalysed by 11 beta-hydroxylase and aldosterone synthase. Using plasma steroid ratios, the level of this process in patients with glucocorticoid-suppressible hyperaldosteronism (GSH) was compared with that in unaffected control subjects and in patients with Conn's syndrome. Based on both 11-deoxycortisol:cortisol (S:F) and 11-deoxycorticosterone:corticosterone (DOC:B) ratios, patients with GSH showed impaired resting 11 beta-hydroxylase activity. In GSH, but not in the other groups, the S:F ratio was significantly correlated with basal plasma aldosterone concentration. ACTH infusion increased the S:F ratio in all these patient groups, suggesting a common partial deficiency. The results also indicate that 11 beta-hydroxylation may be rate-limiting in normal subjects. In control subjects and patients with Conn's syndrome, the DOC:B ratio was not affected by ACTH. However, in GSH patients, this ratio fell markedly, indicating an increased efficiency of 11 beta-hydroxylation of DOC (but not S). This may be due to the activation by ACTH of the zona fasciculata chimaeric aldosterone synthase characteristic of this disease. Plasma aldosterone, corticosterone and DOC concentrations, appeared to ...Continue Reading

References

Mar 1, 1978·Journal of Steroid Biochemistry·R Fraser, C P Lantos
Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·S Y Tan, P J Mulrow
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L PascoeP C White
Feb 1, 1967·The Journal of Clinical Endocrinology and Metabolism·M I New, R E Peterson
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·C E Gomez-SanchezM H Weinberger
Jul 1, 1994·Archives of Disease in Childhood·A JamiesonJ M Connell
May 1, 1996·Clinical and Experimental Pharmacology & Physiology·J M ConnellR Fraser

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Citations

Sep 12, 2000·Current Hypertension Reports·D G Warnock
Nov 22, 2014·The Journal of Endocrinology·F McManusE M Freel
Jun 21, 2003·Journal of Hypertension·Eleanor Davies, Christopher J Kenyon
Dec 7, 2006·Current Hypertension Reports·Scott M Mackenzie, John Connell
Mar 26, 2003·Hypertension·John M C ConnellEleanor Davies
Jul 11, 2006·Pharmacology & Therapeutics·Reem H Elbekai, Ayman O S El-Kadi
Feb 26, 2008·Trends in Endocrinology and Metabolism : TEM·Saroj Nimkarn, Maria I New

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