11 beta-hydroxysteroid dehydrogenase 2 promoter methylation is associated with placental protein expression in small for gestational age newborns

Steroids
Maria-Luisa Lazo-de-la-Vega-MonroyGloria Barbosa-Sabanero

Abstract

Small for gestational age infants have greater risk of developing metabolic diseases in adult life. It has been suggested that low birth weight may result from glucocorticoid excess in utero, a key mechanism in fetal programming. The placental enzyme 11-beta hydroxysteroid dehydrogenase type 2 (11β-HSD2, HSD11B2 gene) acts as a barrier protecting the fetus from maternal corticosteroid deleterious effects. Low placental 11β-HSD2 transcription and activity have been associated with low birth weight, yet the mechanism regulating its protein expression is not fully understood. In the present study we aimed to analyze 11β-HSD2 protein expression in placentas of adequate and small for gestational age (AGA and SGA, respectively) newborns from healthy mothers, and to explore whether 11β-HSD2 protein expression could be modulated by DNA methylation. 11β-HSD2 protein levels were measured by western blot in placental biopsies from term AGA and SGA infants (n=10 per group). DNA methylation was profiled both globally and in the HSD11B2 promoter by liquid chromatography with UV detection and methylation-specific melting curve analysis, respectively. We found lower placental 11β-HSD2 protein expression and higher HSD11B2 promoter methylation ...Continue Reading

Citations

Feb 16, 2019·The Journal of Clinical Endocrinology and Metabolism·Nimesh A JayasuriyaGordon C S Smith
Mar 3, 2020·Nutrition Research Reviews·Ericka Moreno-MendezMaria-Luisa Lazo-de-la-Vega-Monroy
Sep 19, 2018·Cellular and Molecular Life Sciences : CMLS·Ping ZhuKang Sun
Jan 9, 2021·Molecular Medicine·Giulia F Del GobboRyan K C Yuen

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