11 beta-Hydroxysteroid dehydrogenase: fact or fancy?

Steroids
C Monder, C H Shackleton

Abstract

Previous attempts to explain the diverse behavior of 11 beta-hydroxysteroid dehydrogenase (11-HSD) within and between species have not been successful. We now propose that 11-HSD activity is the resultant of the coordinated interaction of two enzyme types, 11-dehydrogenase and 11-reductase. We have demonstrated their separate existence by physico-chemical and kinetic methods. Based on these findings, two classes of disease in humans that have been recently described can now be characterized as being associated with a deficiency in either 11-dehydrogenase or 11-reductase.

References

Oct 26, 1976·Biochimica Et Biophysica Acta·C Tanford, J A Reynolds
Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·S UlickM I New
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·B E Murphy
May 2, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·N F TaylorC H Shackleton
Jul 1, 1979·Journal of Steroid Biochemistry·B E Murphy
Jul 1, 1979·Journal of Steroid Biochemistry·C H ShackletonN F Taylor
Jan 1, 1977·Biology of the Neonate·N J Michaud, A F Burton
Jan 1, 1979·Acta Endocrinologica·E VanlucheneD V Vandekerckhove
Feb 1, 1977·Southern Medical Journal·A R Mawson
Apr 1, 1977·The Journal of Clinical Endocrinology and Metabolism·S UlickM I New
Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·B E Murphy
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·A K TanswellB T Smith
Mar 25, 1975·Biochimica Et Biophysica Acta·A Helenius, K Simons
Feb 1, 1975·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R GhrafH Schriefers
Jun 1, 1989·Journal of Steroid Biochemistry·C MonderJ E Rosen
Jan 1, 1985·The Journal of Endocrinology·R G ClarkI C Robinson
Mar 1, 1985·Journal of Steroid Biochemistry·G Phillipou, B A Higgins
Nov 1, 1966·Endocrinology·D R Koerner
Mar 1, 1968·The Biochemical Journal·I E BushR A Meigs
Mar 4, 1969·Biochimica Et Biophysica Acta·D R Koerner
Dec 1, 1974·The Journal of Clinical Endocrinology and Metabolism·B ZumoffL Hellman
Feb 15, 1974·American Journal of Obstetrics and Gynecology·B E MurphyD Vedady
Oct 1, 1971·The Journal of Clinical Endocrinology and Metabolism·M SchweitzerC J Giroud
Sep 1, 1971·Steroids·J G SowellR C Troop
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·P De Moor, R Deckx
Nov 1, 1969·The Journal of Clinical Endocrinology and Metabolism·G P KleinC J Giroud
May 1, 1968·Canadian Journal of Biochemistry·A F Burton, R W Turnell
Jul 1, 1969·The Journal of Endocrinology·D C SavageJ Cameron
Feb 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S E OberfieldM I New
Dec 1, 1983·Archives of Disease in Childhood·J W HonourV Shah

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Citations

Aug 5, 2005·Cell and Tissue Research·Matthew P HardyChantal Sottas
Apr 1, 1989·Journal of Steroid Biochemistry·W SchulzK Hierholzer
Dec 1, 1993·Steroids·P M StewartB R Walker
Feb 1, 1994·Steroids·A Náray-Fejes-Tóth, G Fejes-Tóth
Apr 1, 1995·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Jun 1, 1995·Molecular and Cellular Endocrinology·K Yang, S G Matthews
Nov 14, 1991·Biochimica Et Biophysica Acta·C MonderY Miroff
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·P M Stewart, C R Edwards
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C Monder
Jan 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C B WhorwoodP M Stewart
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·R S AddisonG R Cannell
Nov 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·C B WhorwoodP M Stewart
Apr 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·K Yang
Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·N PagéM V Govindan
Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·K Yang, M Yu
Feb 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·E Maser, G Bannenberg
May 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·T CronholmJ Sjövall
Mar 28, 1997·Molecular and Cellular Endocrinology·W A DaviesG J Pepe
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A Náray-Fejes-TóthG Fejes-Tóth
Apr 12, 2000·Kidney International·P Ferrari, Z Krozowski
Nov 3, 1991·The New England Journal of Medicine·R V FareseR Gomez-Fontes
Oct 1, 1993·Clinical and Experimental Pharmacology & Physiology·Y TakedaR Takeda
Feb 1, 1991·American Journal of Respiratory Cell and Molecular Biology·R P Schleimer
Jun 20, 1986·Journal of Chromatography·C H Shackleton
May 25, 2004·Journal of Cellular Biochemistry·Marisa Laura ZallocchiMaría Cristina Damasco

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